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Now Live: The March 2013 Issue Of Popular Science Magazine

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Brain PowerMedi-Mation
Jacob Ward, editor-in-chief of Popular Science, wonders why we can't get into the same funding spirit for science as we do for supertall skyscrapers.

Why do we build incredibly tall buildings? What is it in the human psyche that requires us to go higher? Is it a masculinity problem? A desire to touch God? An unholy need to see all of the Earth at once?

The early-Modernist architect Le Corbusier designed, in 1922, a "Contemporary City" for three million people. Decades before the engineering was possible, he imagined a cluster of 60-story towers that would bring a metropolis together in a single vertical habitat, leaving the surrounding countryside open.

It was a revolutionary idea, but it turns out that skyscrapers beget more skyscrapers, not pristine farmland, because centralizing people into vertical habitats is a matter of economics, not land management.

Now architects are redefining the notion of "tall." Supertalls, as Clay Risen describes them, are a mystery to me. People wish to work and live in tall towers, okay-but do they really want to work and live a full mile above the Earth?

And yet financial backers pour money into these projects, funding the creation of the world's tallest buildings seemingly for the hell of it.

Why can't we get the supertall spirit into the public financing of science?Why can't we get the supertall spirit into the public financing of science? The average NSF grant is $159,000, while the tallest buildings in the world cost more than 100 times that.

Investigating the brain used to be something scientists did seemingly for the hell of it. The field of neuroscience wasn't considered a legitimate discipline until 1969. Today, we're pinning down the brain functions that govern sight, hearing, and dementia, and it looks as though we'll soon be able to manipulate them. And yet the public funding that makes this research possible only narrowly escaped major cuts in January, as Washington steered away from the fiscal cliff. It's likely that NSF research money will come under threat again this year. These days, the most far-out brain research probably looks as pointless to a Senate staffer as a mile-high tower does to me.

But that's the thing. Audacious, open-ended endeavors tend to yield big, unexpected rewards. The engineering of supertalls is undoubtedly going to give rise to new materials, new seismic protections, and new aerodynamic shapes that will transform our lives down here on the ground. Maybe the financial world is doing us all a favor by throwing so much private money at these otherwise insane projects. In the same way, let's throw public money at understanding our own brains. We'd be crazy not to.

--Jacob Ward

jacob.ward@popsci.com | @_jacobward_

Go here to read the March issue of Popular Science.




The Rise Of The Supertalls

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Engineering advances have architects striving for the mile-high skyscraper.


On the morning of September 11, 2001, Bill Baker, a structural engineer with the architecture firm Skidmore, Owings and Merrill (SOM), was at his office in downtown Chicago. SOM is the undisputed leader in skyscraper design, and, at least on the engineering side, Baker is its undisputed king. In the past 30 years, he has overseen or worked on six of the world's 15 tallest buildings. But 9/11 was a bad day to be king: As the World Trade Center collapsed and rumors circulated about a rogue plane headed for the Sears Tower, Baker and his colleagues watched as the symbols of their profession became objects of terror.

A few days later, Baker and some of his co-workers drove to New York. The contractors at ground zero needed volunteer engineers to help take apart the towers. "They broke up the site into four zones," he said. "Each zone had four structural-engineering teams, and we were the Chicago team." As Baker picked through the rubble, it was hard not to question the future of high-rise architecture. One article in The Associated Press noted that architects were asking bluntly, "Should we ever build iconic skyscrapers again?"

Barely 18 months after 9/11, Baker returned to New York-this time to talk about designing the world's tallest building. The firm won the contract; six years later, the Burj Khalifa in Dubai topped out at 2,717 feet, more than half a mile tall.

Rather than an era of architectural modesty, the decade since 9/11 has seen a flowering of skyscraper construction. In the 70 years before 9/11, the record for the tallest building grew 230 feet. Since then, it has shot up 1,234 feet. And it's poised to rise much higher over the next decade. Today's tallest skyscrapers are new in every respect: new structures, new materials, designed and tested with new methods. The result isn't just taller buildings but an entirely new category of building: the supertall skyscraper.

Technically, the supertall category, as defined by the Council on Tall Buildings and Urban Habitat, covers anything taller than 300 meters, or 984 feet. That includes the 1,250-foot Empire State Building, a supertall half a century before the term's invention. The two World Trade Center towers, which began to rise in 1966, reached 1,368 and 1,362 feet. But only within the past 15 years have architects and engineers begun to see supertalls as a separate class, with its own challenges and opportunities. "When you get above the World Trade Center size, you've got to change your fundamental thought process," Baker says.

Baker is a tall, professorial type given to illustrating his comments with back-of-a-napkin sketches. Last October, we met for coffee across the street from 30 Rockefeller Plaza in New York. The iconic 850-foot tower opened in 1933, capping a frenzied era of ultra-tall-skyscraper construction. Then the growing stopped. For the next 30 years, steel-frame towers like 30 Rock and the Empire State Building seemed to be as high as architects could go.

That began to change in the mid-1960s, when an engineer named Fazlur Khan, one of Baker's predecessors at SOM, introduced a new structural system called the tube. Khan replaced the traditional internal steel frame with a series of columns running up the outside of the building. The columns are connected to one another and to the building's core, which houses the elevators, stairs, and utilities. That way, the strongest part of the building is on the outside, where it can best resist wind-which, above 40 stories or so, can be a greater concern than gravity.

The advent of the tube set off a surge in tall buildings in the '60s and '70s, including the John Hancock Center, the Sears Tower, and the World Trade Center. But by the time Baker arrived at SOM in the early 1980s, architects and engineers had run into new problems. The tube has a major limitation: It can go as high as an architect wants but only if the base grows proportionally. "If you make it twice as tall, you have to make it twice as wide and twice as deep, and the volume goes up by a factor of eight," Baker says. That won't work for a supertall building-150 floors means several million square feet of office space, much of it deep inside the building, enough to make investors nervously loosen their ties and look for the closest exit.

In the mid-1990s, two things happened that helped push architects beyond the floor-space conundrum, both of which were critical in unleashing the supertall revolution. The first was economic. The tallest skyscrapers used to contain mostly office space. Now supertalls are home to hotels, condominiums, shopping centers, and restaurants. Residential and retail spaces require narrower floor plates than offices, which allows buildings to go higher with the same amount of material while also providing a diversity of real-estate options that make very tall buildings easier to fill. In 2000, only five of the 20 tallest buildings in the world were mixed-use; by 2020, only five won't be.

The move to mixed-use towers facilitated the second big shift in skyscraper design: discarding the tube itself. In 1998, Baker and Adrian Smith-an SOM architect who designed many of the firm's tallest projects, including the Burj Khalifa, before leaving to start his own company-released their plan for Chicago's 7 South Dearborn. The tower was supermodel-slim: It would have risen 2,000 feet on just a quarter of a city block. Instead of a tube, they used a "stayed mast," which featured a central core closely surrounded by eight enormous columns, out from which cantilever the top 60 of 108 stories of mixed-use space.

The dot-com recession scotched the construction of 7 South Dearborn, but its innovative approach inspired architects and engineers to design dozens of "post-tube" skyscrapers. Baker and Smith teamed up again on the Burj Khalifa, and again they came up with an entirely new structural system, the "buttressed core." It involves a central, hexagonal, concrete core, on three sides of which they placed triangular buttresses. Imagine a rocket ship with three long, thin stabilizing fins.

Of course, it's not enough simply to design a tall building; architects and engineers also have to figure out how to move people through it. They've turned to solutions including sky lobbies, double-decker elevators, and so-called destination-dispatch elevators. Still, even the smartest elevators can rise at only about a kilometer a minute and descend at only about two thirds of that-otherwise most passengers' ears can't withstand the pressure.

To go even higher will require a radical rethinking of the elevator itself. "If you're going really tall, then you've got to get rid of the cables," says Leslie Robertson, the chief structural engineer for the original World Trade Center. The practical limit of conventional hoist elevators, he said, is about 1,500 feet. "You need, for example, a car that's driven electromagnetically. That's certainly the wave of the future."

Last year, a company called MagneMotion unveiled a cableless elevator powered by a linear synchronous motor, akin to the maglev motors on some trains. MagneMotion's elevator, developed for the U.S. Navy, is designed to move ammunition around a ship, but the company says it could easily adapt it for passengers.

Today's supertalls are different both in design and composition. Steel was once the material of choice for high-rise buildings, but engineers have begun to jettison steel in favor of concrete. Leonard Joseph, a structural engineer with the firm Thornton Tomasetti, says, "This concrete is not your grandpa's cement and stone and water." Rather, it involves complex recipes of chemicals and advanced materials, including microfibers that can replace bulky steel rebar.

Structural steel has a compressive strength of about 250 megapascals; in the 1950s, the strongest concrete could withstand about 21 megapascals, limiting all-concrete structures to about 20 floors. Today's strongest concrete tops 130 megapascals, and the addition of microfibers could nearly double that number. 
Another advantage is that concrete structures have a greater mass than steel structures-thus a concrete tower can be thinner than a steel one and still have the same resistance to wind forces. Concrete, unlike steel, doesn't need fireproofing.

As some engineers move toward concrete, others are already thinking beyond it, to carbon-fiber composites, the same lightweight, superstrong material that provides the structure in racing bikes and jet aircraft. But scientists will need to work out some significant challenges. Not only is carbon fiber very expensive, but its advantage-its lightness-would also be disturbing for anyone inside the building. People are used to the solidity of concrete and steel under their feet; in a carbon-fiber building, they would feel like they were walking on a drumhead, a disconcerting sensation at 1,500 feet.

As buildings rise taller, they face a series of increasingly complex forces. At ground level, a breeze might barely register. A hundred floors up, it could be gusting at 40 mph. Of particular concern to engineers is something called vortex shedding: As wind passes the sharp edges of buildings, it creates eddies, which pull on the structures in unpredictable ways.

The ability of engineers to model external forces has also enabled the growth of buildings. Until the 1970s, engineers had to overdesign towers with redundant strength because there was no way to test a building until it was built. Around that time, engineers began wind-tunnel-testing models. But it wasn't until fast, cheap computing power and 3-D printing arrived that design firms could test many scenarios rapidly.

These days wind-engineering firms can churn out multiple 3-D models of a building in hours, then test them in quick succession in a specialized wind tunnel. "They can go through 18 variations in a day," says Baker. "It's a long day, but still." Hundreds of sensors cover each model, taking hundreds of pressure readings a second that engineers later feed into a computer simulation that shows where the building is weakest. Toward the end of the process, they even re-create a scale version of its surroundings: hills, other buildings, even pedestrians, all of which create complex wind patterns.

Wind-tunnel analysis has helped engineers develop solutions to vortex shedding, such as rounded edges and notches at a building's corners, and dampers-similar to shock absorbers-that reduce a tower's tendency to move in the breeze. Without them, many supertalls would sway wildly; even if they didn't fall apart, they'd be impossible to work in. "You're on top of a wet noodle, and you get a really sickening ride," Joseph says.

In 1906, not long into the dawn of the skyscraper age, the landscape architect H.A. Caparn called the new building type "a revolt against the laws of economics." The only justification for going so tall, he said, was ego and money. More than a hundred years later, critics still level that charge. It's no coincidence, they say, that supertalls are concentrated in places like the Persian Gulf and China. They're like architectonic hothouse flowers, growing in the artificial climate of money and bad sense.

Yet rather than a revolt against economics, supertalls could be its purest expression. Dubai and Shanghai aren't ancient Egypt or 17th-century France, where a monarch could will a pyramid or palace into existence. The market, not the man, determines whether a supertall gets built.

Take, for example, the Burj Khalifa. On its own, the building represents valuable real estate. But its developer, Emaar Properties, also made it the centerpiece of a new business and residential district, charging a premium for properties with clear views of the skyscraper. Even if the Burj Khalifa fails to turn a profit, Emaar is betting that its presence will raise the surrounding property value enough to more than offset the difference.


Real-estate bets aside, something more fundamental drives the proliferation of supertalls: demographics. By 2050, the world population will have grown to nine billion, from about seven billion today. Some 70 percent of that population will live in urban areas.

For much of the 20th century, urban planning in the developed and developing world was antiurban; the dense verticality of the industrial city was supposed to be a thing of the past. Supertalls represent not just the rejection of that vision but also an embrace of a new synthesis: vertical urbanism.

Buildings like the Burj Khalifa and the Shanghai Tower are often called vertical cities, but they have none of the cluttered vibrancy of 19th-century London or New York's Lower East Side. In Hong Kong, the 1,588-foot International Commerce Center has its own airport rail link; that combined with a high-end mall, office space, and a hotel inside the tower means visitors can fly into the city, spend weeks in the I.C.C.-and never take a breath of the local air.

Whether we like it or not, that's the promise of supertall skyscrapers. In 2017, Kingdom Tower in Jeddah, Saudi Arabia, designed by Adrian Smith, will open at an estimated 3,280 feet, replacing the Burj Khalifa as the world's tallest building. Sitting inside the café at Rockefeller Center with Baker, I asked him whether the Kingdom Tower, at well over a half-mile high, might represent the outer limits of what man could design. Could he do, say, a mile? He thought about it for a moment. "Sure," he said. All he needed was the right client.

Clay Risen is an editor for The New York Times op-ed section. This article originally appeared in the March 2013 issue of the magazine.



Why Mosh Pits Make For A Good Physics Lesson

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Actual Mosh Pit Look! It's the physics of atoms of gas. kimirootsabove / Flickr
Heavy metal music helps researchers better understand panicked crowds.

Have moshers been taking physics lessons? While swarms of sweaty, raging humans might look like anarchy, physicists at Cornell say heavy metal pits actually follow a certain logic, and it is similar to that of gaseous particles. That insight could be used to help predict how crowds behave in emergencies, which, in turn, could help generate better evacuation strategies--ones that even save lives.

Moshing and gas science mixed when Jesse Silverberg, a Cornell graduate physics student and mosh aficionado, brought his girlfriend to her first heavy metal concert. Amid the booziness and ear-ravaging music, Silverberg was struck by the possibility that moshers' slam-happy moves bore a resemblance to collective movements found in nature, such as those of bird flocks and schools of fish.

To study his idea, Silverberg and two accomplices from his program -- Matthew Bierbaum and James Sethna -- snagged YouTube videos of people crashing into each other at metal concerts. They cleaned up the video to remove distortion and shaky camera work, and converted the movements into a two-dimensional plane. In that form, the moshers looked a lot like atoms moving around in gas, the researchers realized.

But the team wanted to do more than watch YouTube videos -- they wanted to take what they learned and make an interactive model of how these gas molecules might move if they turned into metalheads. So Team Mosh developed a real time mosh pit simulator to test different variables such particle softness and how fast particles collide. Each circle in the simulator represents a human mosher defined as a "simple soft-bodied particle" dubbed Mobile Active Simulated Humanoid (MASHer). And as anyone who has seen a mosh pit knows, not everybody wants to tangle. So Silverberg separated the agro red MASHers from the peaceful, stationary gray bystanders. Turn up the speed in the gaseous mosh pit and you begin to see how innocent molecules might get trampled in the fray.

The good news? The research provides insight into how seemingly chaotic crowds behave. And the better researchers understand that, the easier it is to design exit routes and evacuation strategies that could save lives in an emergency.

Read the fun study, which was published on Cornell arXiv.

Popular Science editor Dave Mosher originally accepted this assignment to get his byline on a story that uses his surname, but failed to find enough time/energy to follow through.

[The Atlantic]



Astronomers: Russia's Meteorite Is Not Related To Today's Near-Earth Asteroid Fly-By

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Meteor MorningScreenshot via YouTube
NASA and the ESA say the two astronomical events are not connected.

Mere hours before an asteroid half the size of a football stadium brushes past Earth with only a few thousand miles to spare, a meteorite hurtled into Central Russia, injuring as many as 1,000 people.

It wouldn't be far-fetched for the two events to be related, since asteroids tend to group together, and many meteorites found on Earth have originated in the asteroid belt. Yet despite the coincidental timing, both the European Space Agency (ESA) and NASA have reported that the two are unrelated.

ESA spokesman Bernhard Von Weyhein has said that there is no connection between meteorite and the asteroid 2012DA14, which is scheduled to pass within about 17,000 miles of Earth today.

NASA has reiterated that fact, telling CNN "They are completely unrelated objects -- it's a strange coincidence they are happening at the same time."

In their official statement, NASA scientists noted that the trajectory of the meteorite differed significantly from that of asteroid 2012 DA14. Looking at the position of the sun in the many videos captured by Russian commuters, the meteor can be seen traveling from north to south, while the asteroid 2012 DA14 is moving in the opposite direction, from south to north.



Watch Live As Asteroid 2012 DA14 Whizzes Past Earth

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An animation of Asteroid 2012 DA14 NASA screenshot
Your complete guide to today's near-earth asteroid flyby

Want to keep tabs on asteroid 2012 DA14 as it whizzes past Earth today? NASA TV and several online astronomy outlets will be tracking this asteroid as it makes its record-setting close shave. This marks the first time there has been an asteroid of this size passing this close that we've known about a year beforehand. No, there's no chance it will hit us, but it will come within 27,630 kilometers (17,168 miles) from the surface of the Earth, inside the ring of geosynchronous satellites girdling our planet Earth. It will be closest to Earth at 2:25 p.m. EST (19:25 UTC).

Find out how you can watch on TV or online as this 50 meter- (164 feet-) wide space rock goes by:

NASA Television will provide commentary starting at 2 p.m. EST (11 a.m. PST, 19:00 UTC) on Friday, Feb. 15. This flyby will provide a unique opportunity for researchers to study a near-Earth object up close. You can either watch the feed below, or on your own television if you get NASA TV, or online here.


Video streaming by Ustream

The half-hour broadcast from NASA's Jet Propulsion Laboratory (JPL) in Pasadena, Calif., will incorporate real-time animation to show the location of the asteroid in relation to Earth, along with live or near real-time views of the asteroid from observatories in Australia, weather permitting.

If you are planning to try and observe this asteroid yourself, here's a detailed article about how to do it.

Here are other webcasts that are planned:

Virtual Telescope Project, Italy

Astronomer Gianluca Masi from the Virtual Telescope Project will provide live views of asteroid 2012 DA14 from Ceccano, Italy, beginning at 5 p.m. EST (2200 GMT). You can watch at this link.

Bareket Observatory, Israel

The Bareket Observatory in Israel will have a free live webcast of the 2012 DA14 asteroid flyby on Friday from at 2 p.m. to 3:30 p.m. EST (19:00 to 20:39 UTC). Here's the link to this webcast.

"The observatory will offer a special live view of the close approach, using a remote telescope coupled with a cooled CCD camera, accessible via the Internet," said the observatory team.

Slooh Space Camera, Africa and Arizona

The Slooh Space Camera webcast will provide views of the asteroid from observatories in the Canary Islands (off the west coast of Africa) and in Arizona. They will also be viewable on iOS and Android mobile devices. Just go to the Slooh website on your device. Slooh's webcast will begin on the 15th at 6 p.m. PST / 9 p.m. EST / 02:00 UTC (2/16). The webcasts will feature real-time commentary by Slooh Space Camera's Paul Cox, astronomer Bob Berman of Astronomy Magazine, and Matt Francis, the manager of Prescott Observatory at Embry-Riddle University in Arizona.

This article was republished with permission from Universe Today.



Eating Decades-Old Novelty Chocolate Bars For Fun And Science

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Gross Old CandyJim Cooke

Our friends over at Deadspin have undertaken one of the most pressing and important scientific experiments of our time: to eat decades-old candy bars branded with the faces of Kirby Puckett, Ken Griffey, Jr., and more, and see if they die. Plus, some interesting info in there about what actually happens to candy over time, and whether old packaged food like this really can be toxic (or whether it at least tastes good, unlike this stuff). Check it out here.



Mystery Animal Contest: Who Is This Colorful Creature?

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Mystery Animal: February 15, 2013Wikimedia Commons
Guess the species (either common or Linnaean) by tweeting at us--we're @PopSci--and get your name listed right here! Plus eternal glory, obviously. Update: We have a winner!

So, here are the rules: To answer, follow us on Twitter and tweet at us with the hashtag #mysteryanimal. For example:

Hey @PopSci, is the #mysteryanimal a baboon?

And then I might say "if you think that's a baboon, perhaps you are the baboon!" But probably not, because this is a positive environment and all guesses are welcome and also this is not a very common animal so guess whatever you want!

The first person to get it right wins! We'll retweet the answer from @PopSci, and also update this post so your amazing animal knowledge will be permanently etched onto the internet. Show your kids! Your dumb kids who thought that was a baboon!

Update: And the winner is... @atanas_tanevski, who correctly guessed that this is a Bobbit worm, Eunice aphroditois. We love all animals here at PopSci, but if there was one that represents our nightmares, it'd be the exceedingly strange and terrifying Bobbit worm. It's an oceanic predatory worm, living in the warm waters of the Indo-Pacific Oceans. What you see up there is barely the head of the worm--it commonly reaches lengths of 10 feet (!). Those things branching off the side of its head aren't tentacles or whiskers, they're jaws, which the Bobbit worm uses to leap up and snatch fish, which it drags down into its watery home. Oh, and it's covered in venomous spikes that cause permanent numbness in humans. It's no wonder the Bobbit was the inspiration for the sandworms in the movie Dune.

Bobbit Worm - Dinner time from liquidguru on Vimeo.

The Bobbit worm lives under the seafloor, but it's very adept at hiding despite its large size, so when rocks or coral are dredged and sold to aquariums, some people find themselves playing host to a Bobbit. One Australian aquarium had this issue--it found that some mysterious force was eating all its fish, chomping straight through coral and making quick work of any traps they'd set. Turns out it was a four-foot Bobbit worm.

Very little is known about the Bobbit worm, really. We have no idea about its mating habits or lifespan, though it's suspected due to the unusual length that it may live for a very long time. Anyway, say hello to your new nightmare. Hi Bobbit worm!



How A Radiator Retrofit That Could Save The U.S. Billions Went From Bedroom To Boardroom

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Perfect Temperature Marshall Cox's inexpensive radiator retrofit keeps steam-heated apartments from overheating. A rendering shows how the final version of the Thermostatic Radiator Enclosure will look. TomorrowLabs
Columbia University helped grad student Marshall Cox turn a dorm room hack into a commercializable system that could slash carbon emissions by more than 6 million tons a year.

In 2011, Marshall Cox was living in a university-owned studio apartment in Morningside Heights. His twin brother, a ballet dancer, was living with him temporarily while performing in a Broadway show. Sleeping near the open window, his brother complained about the cold, while on the other side of the steam-heated apartment, Cox was too hot.

To shut him up, Cox, then a PhD student in electrical engineering at Columbia University, developed a radiator retrofit that can regulate the temperature in steam-heated buildings. Now Cox's freshly formed startup Radiator Labs is developing the retrofit for commercial use. The Thermostatic Radiator Enclosure is scheduled to hit the market before next winter. How Cox turned a home-improvement hack into a commercial contender can be credited in large part to his own entrepreneurial determination--though help from Columbia's technology transfer process didn't hurt, either.

***

The idea came about as Cox, 33, chatted about his heating woes with his advisor, Ioannis Kymissis, who runs the Columbia Laboratory for Unconventional Electronics, a group that researches thinfilm electronics. "It was just sort of a casual conversation," Kymissis says -- one of a thousand different ideas he and Cox bat around each week. But this one Cox went ahead and built, putting together a prototype and testing it within his overheated studio apartment.

The invention Cox calls a "glorified oven mitt" fits around your single-pipe radiator and fixes the uncontrollable temperature swings most steam-heated units experience. Today, most new buildings are heated through forced hot air or hot water. But older buildings, especially those built before World War II, use steam heat, and in the 1970s, the rise of double-paned glass windows, which are excellent insulators, radically changed the amount of heat needed to keep a room warm -- and changed it by different amounts for each room -- causing those dramatic temperature swings. This is especially problematic in apartment buildings, where the boiler is all on, or all off, for everyone--there's no halfway with steam heat. So buildings have to cater their heat consumption to the coldest apartment in the unit, leaving residents in some apartments hot and bothered while other units feel comfortable. It isn't just unpleasant, it's bad for the environment: Up to 30 percent of the energy generated by steam heated radiators goes to waste. New York City, an area that uses 20 percent of the nation's steam heat, wastes hundreds of millions of dollars every winter keeping many of its residents uncomfortable.

Cox's "glorified oven mitt" works by trapping heat so that the heat doesn't escape into the room. Some heat leaks out of the cover, but ideally only enough to heat the room on winter's warmer days. When a sensor outside the enclosure determines that the room is too cold, an automatic fan pushes more hot air out of the enclosure and into the room. When the fan is off, the enclosure heats up, trapping the energy that would have been wasted overheating the room in the system as steam, which can then be used to heat colder parts of the building. Cox estimates that if the millions of U.S. housing units with steam-based radiators adopted the technology, they could save billions of dollars in energy costs and reduce carbon emissions by more than 6 million tons--the rough equivalent of removing 1.25 million automobiles from the road.

After building the original prototype, Cox submitted an invention report form to Columbia Technology Ventures. Columbia Technology Ventures is the university's technology transfer office. Its mission is to "facilitate the translation of academic research into practical applications, for the benefit of society." In the process, it helps students and faculty file patents, set up companies and network with industry professionals to help commercialize the research done on campus.

Columbia paid for the initial fees associated with filing a patent (which can cost anywhere from $5,000 to more than $50,000) and helped Cox set up a company. Out of the hundreds of inventions Columbia Technology Ventures deals with each year, only about 15 become startup companies. (More commonly, the tech transfer office helps researchers sell their inventions to existing businesses.) "In order to have a startup you need to have a lot of elements in place," Orin Herskowitz, the executive director for Columbia Technology Ventures, explains. The team involved in the project needs to have the right combination of business and technical know-how, and it has to be a product that has the potential to attract investors.

"Radiator Labs is perfect in that sense," Herskowitz says. The idea could stand on its own -- it wasn't an incremental change in an already established technology from a big company like IMB -- and could be manufactured for a reasonable price. "[Cox] came to us with a great idea that was trying to solve a real need in the marketplace." Herskowitz saw Cox as an entrepreneur who "was clearly not going to stop till he got this thing to the market."

***

When Cox tested his first prototype, he used his own apartment and one radiator. To prove the invention would work on a larger scale, he needed a bigger apartment and more radiators. So Columbia Technology Ventures connected Cox to Columbia's facilities management group, which was more than happy to let him install an energy-saving retrofit--and test its viability--in a university-owned apartment building for free. Having free pilot rights "was hugely powerful," Cox says, because most landlords wouldn't have let him install unproven technology in their building. "We were such an early stage company."

He built wireless capability into the Thermostatic Radiator Enclosure system so that it could connect to the Internet, giving him the ability to look at centralized data from the pilot building and data collected in a control building (also university-owned) next door from anywhere. Unfortunately, he ran into problems with the boiler in his control building, which skewed the data. But the pilot provided practical lessons nonetheless. "We learned a ton of people hate loud fans," Cox explains. "Aesthetics were an issue." The company now had much more data than before on the product, as well as pictures and testimonials from people in the pilot building.

That allowed Cox and his team to take Radiator Labs out on the road, to compete in small business-plan competitions. Depending on the nature of the product, turning an invention into a marketable product can cost anywhere from a few thousand dollars for something like an iPhone app to hundreds of millions of dollars for pharmaceuticals. Columbia covers some upfront costs, but does not fund the entire process. In the spring of 2012, Radiator Labs took $221,000 home as the winner of the MIT Clean Energy Prize, an energy entrepreneurship competition supported by the Department of Energy and the Massachusetts utility company NSTAR. With funding from the Clean Energy Prize, Radiator Labs had the ability to become a serious corporate entity.

***

Now, the product is in a late pilot stage, being tweaked for the commercial market. It should be available this year, in time for the heating season, or next year at the latest. An early stage version of the product might include the option of a wireless receiver, which could allow for direct boiler control and Internet connectivity. It could even give you the ability to adjust the temperature of your apartment from your cell phone. For now, though, the focus is just on getting the product ready to sell. It's likely it'll be available for entire buildings -- since landlords control and pay for heat, they'll be the ones that see the energy savings. Cox -- who successfully defended his dissertation in October and now works full time on Radiator Labs -- also envisions the product as something you could buy for your personal comfort. His goal is to design something easy enough to install yourself, something you could pick up at a home improvement warehouse for just a few hundred dollars.




Space Rocks 101: What You Need To Know About Russia's Meteorite Impact

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It's A Bird! It's A Plane! Screenshot via YouTube
Confused about the difference between a meteorite and a killer asteroid? We've got you covered.

As updates roll in from Russia and the meteorite-related injury toll rises, you may be scrambling to remember what a meteorite really is. If you're a little rusty on your astronomy, here's some basic info about space rocks and why this one was unusual.

What is the difference between all these space rocks?

Asteroid: Any number of celestial bodies smaller than a planet that orbit the sun, between a few kilometers and a few hundred kilometers in diameter.

Comet: An icy body that orbits the sun, like an asteroid, that features a "coma," a thin, temporary atmosphere of gas and dust, and a tail.

Meteor: The glowing streak in the sky we see when an object from space enters the atmosphere and heats up.

Meteoroid: Small rocky or metallic pieces of debris flying through space that can come from a fragment of an asteroid or comet. They can be anywhere from the size of a speck of sand to the size of a large boulder.

Meteorite: The a portion of a meteoroid or asteroid that survives the journey through a planet's atmosphere to make impact.

Bolide: An especially bright meteor -- a fireball that explodes. Geologists use the term when they don't know the nature of an actual projectile to mean a large impactor that forms a crater.

Special bonus definition: Tektite! Pieces of natural glass that are believed to form when meteorites collide with the Earth, rapidly heating up quartz-rich soil and rock and sending the molten material flying over great distances. When it cools, it forms tektites.

When one of these space rocks has an orbit that swings within 1.3 AUs (about the distance between the Earth and the Sun) of our fair planet, it's deemed a near-Earth object.

As much as 100,000 tons of space-stuff lands on Earth every year, most of it dust from collisions in the atmosphere, according to geologist Denton Ebel, the American Museum of Natural History's curator of meteorites. Laurie Leshin, the dean of science at Rensselaer Polytechnic Institute in New York, puts that number at closer to 40,000 tons, but because most cosmic dust collects at the Earth's poles in ice or is collected by high-flying planes, it's difficult to get an exact number.

Addi Bischoff, a University of Muenster mineralogist, told the AP that strikes the size of this one happen five to 10 times a year, but not in an area where they would cause injuries. Most of them land in the desert or the ocean and don't cause much of a ruckus.

"The bigger ones that come in and survive are rarer," he says. The largest known meteorite to hit the Earth is the Hoba meteorite, a 60-ton hunk of iron discovered in Namibia in 1920. It's estimated that it fell less than 80,000 years ago.

What do we know about the meteorite that struck Russia?

Not much, yet. We know that it entered the atmosphere at a shallow angle, and isn't related to the asteroid 2012 DA14.

We don't yet know for certain if the meteorite, a bolide, was made of rock or of iron -- a tightly welded iron meteorite is denser than one made up of a pile of rubble. A statement from the Russian Academy of Sciences estimates the meteor was 10 tons and exploded 20 to 30 miles above the surface of the Earth. During a NASA press conference this afternoon, experts said it was probably not a metallic object because of the way it broke apart.

Don Yeomans of NASA's Near-Earth Object Program told SPACE.com that "if the reports of ground damage can be verified, it might suggest an object whose original size was several meters in extent before entering the atmosphere, fragmenting and exploding due to the unequal pressure on the leading side vs. the trailing side."

It's likely that a sort of CSI: Meteorite will play out as scientists map out the area of destruction and the trail left in the atmosphere to determine the force of the impact and what the explosion must have been like. Right now, all we have to go on is a lot of amateur video.

Once actual data comes in, it's possible that this will change what we know about meteorites. "What we model and what we expect is almost never what we find," Ebel says. "We should expect to be surprised."

Why was this one such a big deal?

The object that blasted through central Russia today has injured more people than any other meteorite Ebel has heard of in human history. It's the biggest object to strike the Earth since the meteorite that exploded over Siberia in 1908, a blast that downed an estimated 80 million trees in an 830-square-mile area.

Near-Earth objects don't often hit urban areas. Though this meteorite may have been one of the largest objects to strike Earth in recent history, it was still relatively tiny -- some three meters in diameter, about the size of a refrigerator, according to Ebel.

Why did so many people get hurt?
Most of the damage seems to have come from the air burst generated when the meteor hit the Earth's atmosphere, moving at an estimated 33,000 miles per hour. Ebel likens it to a truck exploding up in the air. The Russian Academy of Science's estimate is that the meteor shattered between 18 and 32 miles above the Earth, releasing several kilotons of energy and sending meteorites across central Russia and part of Kazakhstan.

In 2003, a meteorite fell in a suburb south of Chicago, showering the area in debris, but it didn't blow out windows, possibly because it exploded higher in the atmosphere. In contrast, the pressure wave from this fireball blew out a ton of windows, injuring those that (understandably) ran to watch the exploding fireball streak across the skyline. The latest count has somewhere around 1,200 people injured, many in the city of Chelyabinsk. Most injuries are not thought to be serious, according to CNN's latest report.



Congressional Hearing Offers A Sneak Peek At The Future Of Domestic Drone Rules

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Multiplex Twin Star Model AirplaneWikimedia Commons
As regulators look at how to allow drones into American airspace, their concerns now will shape our skies tomorrow.

"One of my constituents built a 9-foot flying wing and sends me pictures of my house when he flies over," Representative David Schweikert (R-AZ) said wryly in a Congressional hearing today on how to regulate drones when they are granted expanded access to American airspace in 2015. It was almost the last statement in the hearing--held by the Joint Planning and Development Office (JPDO) before the House Science, Space and Technology oversight subcommittee on unmanned aerial systems (the committee's preferred terminology for drones)--and it captured a few important points about the current state of drone law, and, perhaps, where it's headed.

Privacy
As Schweikert suggests, most Americans are not terribly fond of the idea of their neighbors flying cameras around and taking pictures of them in their backyards. The problem is that, right now, there is no explicit federal guidance prohibiting this. Some states, like Texas, are currently pursuing laws of their own to remedy this. But until then, according to testimony by Dr. Gerald Dillingham, civilian drones are governed by the same rules that apply to model aircraft--which is basically no rules at all.

The problem is that there isn't yet a clear guideline for privacy going forward. Dr. Dillingham, director of civil aviation issues in the Government Accountability Office, testified that while the Federal Aviation Administration has a clear safety mandate, it doesn't have one for privacy. So it would fall to Congress to decide which governmental body--the FAA or some other organization--should draw up privacy regulations. Congress could potentially legislate on those regulations, if, say, members think the rules aren't strict enough, but given Congress's record on privacy expect more lip service than action.

Hacking
The next most pressing concern brought up in today's hearing was hacking. In December 2011, a stealthy U.S. RQ-170 spy drone crashed over Iran. Reportedly, this was the result of "GPS spoofing," a security-attack technique in which you bypass controls and interfere with the machine's internal GPS. While military encryption is supposed to protect against this, it's certainly not perfect. And even if it were, that type of encryption might not be viable for the commercial market, Dr. Edgar Wagoner, testifying on behalf of NASA, said.

These vulnerabilities will have to be addressed before the widespread introduction of commercial drones, because the possibility of easily hacked flying machines is not something anyone is excited about. Dillingham noted that creating a perfectly hack-proof system is impossible. That said, committee co-chairman Representative Dan Maffei specifically pointed out that it wasn't military but commercial aircraft hijacked on 9/11, so expect the House to try and legislate a hack-proof standard anyway.

Control
Another major issue mentioned was drone autonomy. In 2010, a U.S. Navy drone lost contact with its controllers and proceeded to violate D.C. airspace before control could be regained. A drone is, in cases like this, supposed to either immediately plot a course to its home base or attempt to reestablish a connection with its controller. But in this case, it took a half-hour to re-establish contact, which was way too long. Ensuring there are protocols in place to prevent wayward drones was also part of the committee's mission. Currently, the Federal Aviation Administration is conducting a search for drone sites, and one of the reasons why is because officials want to find a way to safely and regularly test drones. Data from those tests will be delivered to the committee and could help shape safety regulations.

Prosperity
The hearing took place as part of the long, ongoing process to figure out how exactly unmanned aerial systems are going to fit into American airspace. Representative Kevin Cramer (R-ND) and Representative Scott Peters (D-CA) both took some of their allotted time to campaign for their districts as commercial drone testing sites, and were positively giddy by the prospect of developing a lucrative drone economy. Dillingham expects that "the worldwide UAS market could be potentially worth $89 billion over the next decade." There's too much money to not have commercial drones.



Fun Game: Create Your Own Custom Meteorite Impact

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Barringer Crater, ArizonaWikimedia Commons
Plug in the numbers and KABOOM! space rocks smash into the Earth.

Purdue University has a fun simulator called Impact Earth that shows you what would happen if a particular kind of meteorite smashed down from space. Plug in some info about the meteorite you'd like to simulate--size, composition, angle and speed of impact--and then check out the precise kind of havoc it would wreak. We've written about it before, but it somehow seems more pressing now. Maybe because of this little thing. Try Impact Earth here.



Shouldn't We Have Been Able To See This Huge Meteorite Coming?

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Fireball Feb. 15NEproskochil/via YouTube
Space rocks are typically tiny and dark. Even if we could spot them, it wouldn't be until they were already upon us, and by then it's too late.

Friday morning's meteor, the largest object to strike Earth in more than a century, took the whole planet by surprise. But maybe it didn't have to.

There's a chance the space rock that careened into Earth's atmosphere over Russia could have been spotted if the right telescope happened to be looking in the right place. That's happened exactly once before. But it's highly unlikely it could have been spotted in enough time to sound an alarm--at least not with our planet's existing warning systems.

International scientists say it's unrelated to the asteroid 2012 DA14, which flew past Earth today. That rock was found in a ground-based sky survey, but at roughly half a football stadium in width, it is much larger than the meteorite.

2012 DA14 was hard enough to find, but the chances of spotting something like this morning's meteorite are really dismal, said Laurie Leshin, dean of science at Rensselaer Polytechnic Institute and former research director of the Center for Meteorite Studies at Arizona State University.

"The rocks themselves tend to be very dark. Most meteorites reflect only a couple percent of the light that hits them," she said. "A lot of them are filled with carbonaceous materials, like coal, basically, so they can be very black."

The unnamed rock packed a gigantic 300-500 kiloton punch when it exploded in the air, blowing out windows, damaging hundreds of buildings and injuring at least 1,200 people. That's a good 20 times the power of the atomic bomb dropped on Hiroshima. The rock was probably about 50 feet in diameter, an estimate derived from two infrasound stations near the impact, according to Peter Jenniskens, a SETI Institute scientist and principal investigator of the Cameras for Allsky Meteor Surveillance at NASA's Ames Research Center. He said that although small, this space rock could have been seen, at least in principle.

"This asteroid could have been detected if we would have been searching for it," he said. "It was not, as far as I know, seen coming in, and there was no prediction that this could happen. But that could have a lot to do with the fact that a survey, at any given time, only covers a small area of sky."

There is one example in the scientific record of an incoming meteorite being discovered before impacting Earth. In the middle of the night between Oct. 5 and Oct. 6, 2008, Richard Kowalski was manning a 1.5-meter telescope belonging to the Catalina Sky Survey near Tucson, Ariz., when he spotted an object ultimately named 2008 TC3. This space rock was only 7 to 16 feet in diameter, much smaller than the one that hit Russia today, and incredibly faint--a magnitude 19 object. His observation came 20 hours before the rock exploded an estimated 23 miles above Sudan's Nubian Desert. The explosion created a 1.2 kiloton shock wave, Jenniskens said.

"(Friday's explosion) was 300 times bigger," he noted. "We could have seen it. It is quite possible that it did go through someone's survey field, or maybe an amateur's telescope." Astronomers will no doubt be combing their records from the past couple of days--probably the earliest it would have been seen--to check if anything crops up.

Randy Korotev, a meteorite expert at Washington University in St. Louis, said many meteorites are agglomerations of non-reflective material that are too tiny to reflect much light. This helps explain why they disintegrate when they enter Earth's atmosphere--they're crumbly.

"When these things hit the atmosphere, from the point of view of the meteorite, it's like hitting concrete. It compresses the air so fast," he said. "Most meteorites can't stand the internal shock themselves. That's why, toward the end, they typically fall apart."

The overwhelming majority of the time, that's how meteors become visible--by turning into a literal fireball, in Leshin's words. "They are glowing from fire, because they are going so fast when they come through our atmosphere," said Leshin. That's true right at their surfaces, she added--inside, meteorites are still ice cold.

Philipp Heck, assistant curator of Meteoritics and Polar Studies at the Field Museum of Natural History in Chicago, said a denser network of small ground-based telescopes and sensitive cameras could theoretically detect a small asteroid like the one that became today's meteor. Or an infrared telescope, which can detect very small items, might be able to spot them.

"A combination of both makes sense. Now, after today, I think people will be more aware of the threats that exist," he said.



A 3-D Printed Plastic House And More Amazing Images From This Week

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A 3-D Printed House This proposal, called Protohouse 2.0, is a plan from architecture collective Softkill Design to build a 3-D printed house. It could be printed in pieces off-site, then taken to a spot and constructed in a single day. Looks very webby. Softkill Design via Dezeen
Plus a valentine from space, a bathroom in a bubble, and more


Click to enter the gallery



This Week In The Future: The Pope's Robot Tentacle Saves Whale Sharks

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This Week In The Future, February 11-15, 2013Baarbarian
In the future, everyone's going to want to look at your vacation photos.

Want to win this awesome Baarbarian illustration on a T-shirt? It's easy! The rules: Follow us on Twitter (we're @PopSci) and retweet our This Week in the Future tweet. One of those lucky retweeters will be chosen to receive a custom T-shirt with this week's Baarbarian illustration on it, thus making the winner the envy of friends, coworkers and everyone else with eyes. (Those who would rather not leave things to chance and just pony up some cash for the T-shirt can do that here.) The stories pictured herein:

And don't forget to check out our other favorite stories of the week:



Archive Gallery: Popular Science Admires the Presidents

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Thomas Jefferson, Inventor: February, 1927
Including Washington, Jefferson, Kennedy and more

Popular Science has seen 28 presidents (Grover Cleveland twice) since its founding in 1872. Though the magazine tries to stay out of politics, there were two presidents whose contributions to science earned them our special admiration: inventor Thomas Jefferson and space-age champion John F. Kennedy.

Other commanders-in-chief, including Abraham Lincoln and George Washington, have also appeared in PopSci, but for less illustrious reasons (in 1929, we centered a whole article around Charles Hotz, a waiter who happened to look exactly like Calvin Coolidge.) Here is a gallery of our presidential coverage, from 1927 to 1989.

See the gallery.

This article originally appeared on PopularScience.com September 7, 2012.




European Researchers Win $1.3 Billion To Simulate The Human Brain

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Human Brain Project The Human Brain Project has ten years to build the brain with supercomputers. courtesy Human Brain Project
Europe just kickstarted the Human Brain Project with massive cash.

Henry Markram, whose simulated rat brain we have covered before, now wants to build a human brain simulator one neuron at a time. That might take a little while, since there are roughly 86 billion neurons crammed in the average person's skull. But then again, Markram just scored funds--one and a half cents for each neuron.

Markram is head of the Switzerland-based Human Brain Project, which won $1.3 billion last month to build the human brain in a silicon substrate. Awarded by the European Commission, the prize will be doled out over the next decade as the researchers model brain cells down to the thousands of synapses on each neuron that pass signals between the cells.

The Human Brain Project is a collaboration between some 80 research institutions in Europe. The team will use supercomputers to investigate how and which genes are expressed by neurons. One big challenge will be figuring out how to differentiate between various types of neurons. Another problem is that the computing power Markram needs doesn't exist yet, but the team will start working on a model to unify brain research efforts in the meantime.

Markram's "Blue Brain" rat brain project is Mickey Mouse business compared to the new project, because Blue Brain models just roughly one million neurons.

The goal is to build computers that can learn new tasks the way a human does, without software upgrades. Markram hopes that one day soon researchers can test new drugs and interventions on an accurate sim-brain for neurodegenerative disorders, like Alzheimer's. Here's their video about the project:

Of course, Markram is not the only scientist in pursuit of recreating man's gray matter. There have even been some fighting words in recent years lobbed by Markram at IBM researchers, who one-upped Markram's rat brain with a cat brain simulation, and last year announced they simulated 10 billion neurons. Read a Q&A with Markram over at Science Mag.

On the other side, there's Spaun, a computer model with 2.5 million simulated neurons. But Spaun comes at the simulation problem from the other direction. Instead of modeling individual neurons, Spaun's scientists model behavioral outcomes.

[NewScientist]



Obama Expected To Launch Massive Study Of The Human Brain

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NeuronsPatrick Hoesly on Flickr

President Obama is planning to back an exhaustive study of the human brain that could help researchers gain insight into everything from Alzheimer's to mental illness to artificial intelligence, the New York Times reports:

The Obama administration is planning a decade-long scientific effort to examine the workings of the human brain and build a comprehensive map of its activity, seeking to do for the brain what the Human Genome Project did for genetics.

The Brain Activity Map project could be unveiled as soon as March and is expected to cost billions of dollars, the Times says.

It differs significantly from the Human Brain Project, the $1.3 billion brain research project Europe unveiled recently. The European project involves simulating the human brain; the Obama proposal focuses on mapping brain activity.

For more amazing brain research, go here.

[The New York Times]



Fusion Power Could Happen Sooner Than You Think

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Lockheed Skunkworks ExteriorWikimedia Commons
A new Lockheed Skunkworks project promises outsized results in a compact package.


In a presentation that seems ripped from the Atomic Age, Lockheed Skunkworks says it might be a decade away from producing a power plant based on compact fusion reactors. Unlike current nuclear reactors, all of which use fission, nuclear fusion does not easily produce materials that can be used in nuclear weapons. Fusion reactors also offer better containment, easier shutoff, greater energy efficiency, and less radioactive waste than their fissioning cousins. Of course, with something this promising, there has to be a catch.

Despite the fact that nuclear fusion has been pursued as a power source since the 1950s, fusion reactors have yet to be effectively turned into a regular power source. Tokamaks, the first kind of fusion reactor attempted, generated power by using magnets to squeeze and heat plasma in a giant ring. To make it work, you need a massive donut-shaped vacuum chamber, and it can take years to go from construction to power generation. There has been something of a modern revival of fusion reactor attempts, but most designs still are tremendous undertakings, requiring the kinds of resources and infrastructure that usually only governments can provide. And such coordination efforts are difficult in the best of times and can be an impossible sell during severe financial constraints.

So in part, it's the feasibility of the new Lockheed project that makes it so compelling. Much smaller than traditional fusion attempts, the compact fusion reactor uses a cylinder, not a ring, which makes for a stronger magnetic containment field and leaves fewer points where the energy could escape. This could make for a reactor that's small enough for a truck to transport and still robust enough to generate power for 100,000 homes. Lockheed hopes to have a test model available by 2017, and scale up to regular production by 2022.



FYI: Do Meteor Showers Ever Run Out of Meteors?

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Meteor MadnessAdastra/Getty Images
Yes, but it takes a long, long time.

Meteor showers occur when the Earth passes through a field of cosmic debris. As that debris crosses into the Earth's atmosphere, each piece burns up, sometimes creating the blazing streaks of light we call shooting stars. These chunks of rock or ice are gone for good, so it's true that a meteor shower loses some of its material, or fuel, with every flurry.

But there are ways for a shower to be replenished, says David Meisel, executive director of the American Meteor Society. The Geminids, which appear every December, are fragments from an asteroid called 3200 Phaethon. When 3200 Phaethon swings past the sun, it heats up and pieces break off, littering its orbit with fuel for shooting stars. Given that the asteroid is about three miles in diameter, it will take a long, long time-"millions of years," says Meisel-for all that material to be exhausted.

Even if the asteroid or comet behind a meteor shower were to break apart altogether, it would still take tens of thousands of years for the dust to disperse. A small portion would burn up in the Earth's atmosphere, but most of the dust would collide with itself and spiral into the sun.
A meteor shower doesn't have to run out of fuel to disappear. The outer planets can tug a comet out of its natural periodicity, such that its debris may lie in Earth's orbital path on one pass and not at all on the next. "You can't depend on a comet to produce a nice, steady stream all the time," says Meisel. "If we understood it all, there would be no fun."

Have a burning science question you'd like to see answered in our FYI section? Email it to fyi@popsci.com.



How Neuroscience Will Fight Five Age-Old Afflictions

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Rewiring The Brain: Seizures a) A surgeon identifies where in the brain seizures occur using electrodes placed on the scalp, then inserts an electrode array directly into that region. b) A seizure starts when neurons become overly excited, causing a prominent electrical signature. The array detects this signature and emits its own electrical pulse, which disrupts the neurons. c) The pulse also puts a negative current on a polymer enveloping the electrodes on the array, causing its charge to change from positive to neutral. Negatively charged antiseizure-drug molecules drop away from the electrodes, further calming the nearby neurons. Medi-Mation
Rewiring the brain to battle seizures, blindness, and more


1) SEIZURES

A device delivers targeted drugs to calm overactive neurons

For years, large clinical trials have treated people with epilepsy using so-called deep-brain stimulation: surgically implanted electrodes that can detect a seizure and stop it with an electrical jolt. The technology leads to a 69 percent reduction in seizures after five years, according to the latest results.

Tracy Cui, a biomedical engineer at the University of Pittsburgh, hopes to improve upon that statistic. Her group has designed an electrode that would deliver both an electrical pulse and antiseizure medication. "We know where we want to apply the drug," Cui says, "so you would not need a lot of it."

To build the device, Cui's team immersed a metal electrode in a solution containing two key ingredients: a molecule called a monomer and the drug CNQX. Zapping the solution with electricity causes the monomers to link together and form a long chain called a polymer. Because the polymer is positively charged, it attracts the negatively charged CNQX, leaving the engineers with their target product: an electrode coated in a film that's infused with the drug.

The researchers then placed the electrodes in a petri dish with rat neurons. Another zap of electricity disrupted the electrostatic attraction in the film, causing the polymer to release its pharmacological payload-and nearby cells to quiet their erratic firing patterns. Cui says her team has successfully repeated the experiment in living rats. Next, she'd like to test the electrodes in epileptic rats and then begin the long process of regulatory approval for human use.

The body's blood-brain barrier protects the organ from everything but the smallest molecules, rendering most drugs ineffective. As a result, this drug-​delivery mechanism could treat other brain disorders, Cui says. The electrodes can be loaded with any kind of small drug-like dopamine or painkillers-
making it useful for treating Parkinson's disease, chronic pain, or even drug addiction.

2) DEMENTIA

Electrode arrays stimulate mental processing

Dementia is one of the most well-known and frustrating brain afflictions. It damages many of the fundamental cognitive functions that make us human: working memory, decision-making, language, and logical reasoning. Alzheimer's, Huntington's, and Parkinson's diseases all lead to dementia, and it's also sometimes associated with multiple sclerosis, AIDS, and the normal process of aging.

Theodore Berger, a biomedical engineer at the University of Southern California, hopes to help people stave off the symptoms of dementia with a device implanted in the brain's prefrontal cortex, a region crucial for sophisticated cognition. He and colleagues at Wake Forest Baptist Medical Center tested the device in a study involving five monkeys and a memory game.

First the team implanted an electrode array so that it could record from layers 2/3 and 5 of the prefrontal cortex and stimulate layer 5. The neural signals that jet back and forth between these areas relate to attention and decision-making. The team then trained the monkeys to play a computer game in which they saw a cartoon picture-such as a truck, lion, or paint palette-and had to select the same image from a panel of pictures 90 seconds later.

The scientists initially analyzed the electrical signals sent between the two cortical layers when the monkeys made a correct match. In later experiments, the team caused the array to emit the same signal just before the monkey made its decision. The animals' accuracy improved by about 10 percent. That effect may be even more profound in an impaired brain. When the monkeys played the same game after receiving a hit of cocaine, their performance dropped by about 20 percent. But electrical stimulation restored their accuracy to normal levels.

Dementia involves far more complicated circuitry than these two layers of the brain. But once scientists better understand exactly how dementia works, it may be possible to combine several implants to each target a specific region.

3) BLINDNESS

Gene therapy converts cells into photoreceptors, restoring eyesight

Millions of people lose their eyesight when disease damages the photoreceptor cells in their retinas. These cells, called rods and cones, play a pivotal role in vision: They convert incoming light into electrical impulses that the brain interprets as an image.

In recent years, a handful of companies have developed electrode-array implants that bypass the damaged cells. A microprocessor translates information from a video camera into electric pulses that stimulate the retina; as a result, blind subjects in clinical trials have been able to distinguish objects and even read very large type. But the implanted arrays have one big drawback: They stimulate only a small number of retinal cells-about 60 out of 100,000-which ultimately limits a person's visual resolution.

A gene therapy being developed by Michigan-based RetroSense could replace thousands of damaged retinal cells. The company's technology targets the layer of the retina containing ganglion cells. Normally, ganglion cells transmit the electric signal from the rods and cones to the brain. But RetroSense inserts a gene that makes the ganglion cells sensitive to light; they take over the job of the photoreceptors. So far, scientists have successfully tested the technology on rodents and monkeys. In rat studies, the gene therapy allowed the animals to see well enough to detect the edge of a platform as they neared it.

The company plans to launch the first clinical trial of the technology next year, with nine subjects blinded by a disease called retinitis pigmentosa. Unlike the surgeries to implant electrode arrays, the procedure to inject gene therapy will take just minutes and requires only local anesthesia. "The visual signal that comes from the ganglion cells may not be encoded in exactly the fashion that they're used to," says Peter Francis, chief medical officer of RetroSense. "But what is likely to happen is that their brain is going to adapt."

4) PARALYSIS

A brain-machine interface controls limbs while sensing what they touch

Last year, clinical trials involving brain implants gave great hope to people with severe spinal cord injuries. Two paralyzed subjects imagined picking up a cup of coffee. Electrode arrays decoded those neural instructions in real time and sent them to a robotic arm, which brought the coffee to their lips.

But to move limbs with any real precision, the brain also requires tactile feedback. Miguel Nicolelis, a biomedical engineer at Duke University, has now demonstrated that brain-machine interfaces can simultaneously control motion and relay a sense of touch-at least in virtual reality.

For the experiment, Nicolelis's team inserted electrodes in two brain areas in monkeys: the motor cortex, which controls movement, and the nearby somatosensory cortex, which interprets touch signals from the outside world. Then the monkeys played a computer game in which they controlled a virtual arm-first by using a joystick and eventually by simply imagining the movement. The arm could touch three identical-looking gray circles. But each circle had a different virtual "texture" that sent a distinct electrical pattern to the monkeys' somatosensory cortex. The monkeys learned to select the texture that produced a treat, proving that the implant was both sending and receiving neural messages.

This year, a study in Brazil will test the ability of 10 to 20 patients with spinal cord injuries to control an exoskeleton using the implant. Nicolelis, an ardent fan of Brazilian soccer, has set a strict timetable for his team: A nonprofit consortium he created, the Walk Again Project, plans to outfit a paraplegic man with a robotic exoskeleton and take him to the 2014 World Cup in São Paulo, where he will deliver the opening kick.

5) DEAFNESS

Stem cells repair a damaged auditory nerve, improving hearing

Over the past 25 years, more than 30,000 people with hearing loss have received an electronic implant that replaces the cochlea, the snail-shaped organ in the inner ear whose cells transform sound waves into electrical signals. The device acts as a microphone, picking up sounds from the environment and transmitting them to the auditory nerve, which carries them on to the brain.

But a cochlear implant won't help the 10 percent of people whose profound hearing loss is caused by damage to the auditory nerve. Fortunately for this group, a team of British scientists has found a way to restore that nerve using stem cells.

The researchers exposed human embryonic stem cells to growth factors, substances that cause them to differentiate into the precursors of auditory neurons. Then they injected some 50,000 of these cells into the cochleas of gerbils whose auditory nerves had been damaged. (Gerbils are often used as models of deafness because their range of hearing is similar to that of people.) Three months after the transplant, about one third of the original number of auditory neurons had been restored; some appeared to form projections that connected to the brain stem. The animals' hearing improved, on average, by 46 percent.

It will be years before the technique is tested in humans. Once it is, researchers say, it has the potential to help not only those with nerve damage but also people with more widespread impairment whose auditory nerve must be repaired in order to receive a cochlear implant.

This article originally appeared in the March 2013 issue of the magazine.



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