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9 Things You Didn't Know About Poison

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Golden Poison Frog (Phyllobates terribilis)
© AMNH/T. Grant

A new exhibit at the American Museum of Natural History explores the weird and wonderful world of poisons. Curated by evolutionary biologist Mark Siddall, “The Power of Poison” recreates a Columbian forest filled with deadly natural toxins, delves into the history of criminal ;poisonings, and brings to life famous fictional characters to investigate the science behind mythical poisons. The exhibit, which opened Saturday and runs through August 20, 2014, ends by examining how otherwise-deadly toxins can be used in medicine.

Here are nine little-known facts about poison you can impress your relatives with over Thanksgiving dinner. Or not.


    







Can Organisms Evolve The Ability To Evolve?

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scanning electron micrograph image of the Lyme disease-causing bacteria
Borrelia burgdorferi Bacteria
Electron scanning micrograph. Color added digitally.
Photo credit: Janice Haney Carr. Content Provider: CDC/Claudia Molins.

Can things evolve to evolve? Okay, so that sounds like a cheesy line from a self-help book, but what I'm talking about here is actual biological evolution. Depending on the situation, evolution is obviously able to drive the development of traits like rapid cooling, camouflaging color, or fecundity. But one team of U.S. biologists got to wondering whether quick evolution itself was a trait selected for by evolution.

At least in microbes, flexibility and "evolvability" really are selected for, the team found in a study. The study, the team says, offers the first direct evidence of this happening.

The idea of evolution driving evolvability is "highly controversial," the team, including biologists from the University of Pennsylvania and the University of Kentucky, wrote in their paper, published in the journal PLOS Pathogens. Although many quickly evolving creatures are successful, it seems strange that evolution should build that into organisms. After all, evolution should be as blind to the future as your local psychic (Sorrynotsorry). Natural selection selects for traits that are useful right now. Sometimes those traits happen to be useful to later generations in unexpected ways, but there's no mechanism in evolution to actively prepare for the future, which is what evolvability does.

Nevertheless, to look for some real-world evidence of selection acting on evolvability, the Pennsylvania and Kentucky biologists examined Borrelia burgdorferi, the bacteria species that gives people Lyme disease.

There's no mechanism in evolution to actively prepare for the future, which is what evolvability does.

Like all infectious microbes, B. burgdorferi make proteins that appear on their surfaces. To fight off infection, the immune system learns to recognize these proteins, latch onto them, and kill off B. burgdorferi cells. In a counter-move, B. burgdorferi sometimes changes its surface proteins, a feat that requires it to change its very DNA. Luckily, B. burgdorferi bacteria often carry a bunch of unused DNA, called cassettes, that are able to quickly become working DNA, offering instructions for making different surface proteins that are unrecognizable to the infectee's immune system. Sneaky!

By analyzing 12 different strains of B. burgdorferi, the team found evidence there's strong selective pressure for the bacteria to develop a diverse collection of unused cassettes that would give them more varied surface proteins. Evolution doesn't need to be able to see the future to do this, the team writes. Selection for such a trait could happen during active infections, when host immune systems kill off less evolvable B. burgdorferi, or through reproduction, if more evolvable B. burgdorferi are more likely to produce offspring with a variety of cassettes.

This likely doesn't happen in organisms such as animals, plants and fungi, however, the team writes. The way those cells work, latent evolvability isn't so directly linked to traits important to their survival. So for humans, at least, the idea of evolving to evolve will have to stay in the self-help books.


    






The Worst Jobs In Science

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Bush-Meat Market Data Collector
Sure, everyone loves monkeys. But few test that love like Jake Owens. An environmental science Ph.D. candidate at Drexel University, Owens studies the ecology and behavior of drill monkeys. Typically, that involves trips to places like Bioko, an island off Africa’s western coast, where he crawls through snake-infested vegetation to collect monkey dung. In 2010, Owens had to survey an illegal bush-meat market in Equatorial Guinea, where merchants sell meat from endangered primates. Amid the stench of rotting flesh, he took hundreds of hair and tissue samples from the monkeys for isotope analysis. Using this data, Owens aims to locate poaching hot zones. “Most people at the market hated me or the effort to stop poaching that I represent, and they didn’t hide it well,” Owens says. The merchants regularly swatted him with brooms, spat at his feet, and waved blowtorches and machetes to keep him away. The reward for Owens’s perseverance? A mysterious monthlong illness that caused his hair to fall out.
Chris Philpot

Click here to enter the gallery


    






First Satellite Built By High School Students Launches Tonight

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NASA Ames engineers are building PhoneSats, demonstrating how "off the shelf" consumer devices can lead to new space exploration capabilities.
NASA Ames Research Center/Dominic Hart

Orbital Sciences' Minotaur 1 rocket is carrying some historic cargo to space today. Alongside NASA's latest smartphone-enabled PhoneSat 2.4 is another tiny satellite, called TJ3Sat, built by students at Thomas Jefferson High School for Science and Technology. This CubeSat is the first satellite built by high school students and is set to launch from the Wallops Flight Facility in Virginia at 7:30 p.m. EST.

This will be the Minotaur 1's 25th mission, and the rocket will be carrying a record of 28 CubeSats—4-inch-cube satellites based around smartphone technology. An out-of-the-box smartphone is housed within the CubeSat structure, making for a relatively inexpensive spacecraft. Three of NASA's PhoneSats have successfully spent about a week in orbit. PhoneSat 2.4 will go into a higher orbit than any other PhoneSat has before.

As a part of NASA's Educational Launch of NanoSatellites (ELaNa) program, the Thomas Jefferson High School students' 2-pound satellite is the culmination of seven years of work by more than 50 students. ELaNa aims to attract students to study STEM disciplines, which matches up well with TJ3Sat's mission. Once in orbit, the CubeSat will send and receive data from students and other amateur radio users on Earth. Submissions can be made via their website, and approved strings of text will be sent to the satellite in space. In return, Earthling users will receive a voice interpretation of the text via radio frequency.

“It used to be that kids growing up wanted to be an astronaut. I think we might be seeing kids saying, what they want to do is build a spacecraft. The idea here is that they really can do that,” Andrew Petro, program executive for small spacecraft technology at NASA, said in a statement. “They can get together with a few other people to build and fly a spacecraft. Some students coming out of college as new hires have already built and flown a satellite . . . that’s a whole new notion, one that was not possible even 10 years ago."


    






Watch Blade Runner, Made In More Than 12,000 Watercolor Paintings

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Blade Runner, director Ridley Scott's 1982 masterpiece, is the greatest science-fiction movie ever made.

But what about Star Wars, dummy?

No. It is Blade Runner

If you haven't seen it--then my Lord, what are you doing, go watch the director's cut version by any means possible--the movie follows Rick Deckard (Harrison Ford), who's tasked with hunting down a gang of rogue androids. There is action. There is philosophy. And the whole dystopian cityscape looks like a brooding Impressionist painting. Which makes this tribute by artist Anders Ramsell, a 30-plus-minute "paraphrase" of the film done in more than 12,000 aquarelle paintings, especially moving. It's the washed-out, surreal feeling the movie already cultivates, but reinterpreted. Like tears in rain.

[Digg]


    






Engineering The Sour

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Basil Daiquiri
The Margarita, the Daiquiri, the Cosmopolitan, the Whiskey Sour, the Mai Tai: These and hundreds of other popular drinks can all be boiled down to one basic recipe format from one basic cocktail family: the Sour. And once you understand it (which won’t take long), you can create hundreds of new drink recipes using the same format, with whatever ingredients you have on hand.

Simply put, a Sour is a drink consisting of a base liquor plus a sour component balanced against a sweet component. A Daiquiri uses rum, lime, and sugar. A Bee's Knees calls for gin, lemon, and honey syrup. A Margarita mixes tequila, lime, and orange liqueur. The basic formula for a Sour is 2 parts of the base spirit to 1 part of the sweet component and 1 part of the sour component.

For example:

Daiquiri
2 parts white rum
1 part simple syrup
1 part fresh lime juice

Shake ingredients with ice and strain into a cocktail glass, or strain onto new ice in a rocks glass.

Cocktail recipes and definitions change with the times (just like language), so we’re taking a broad and modern view of a Sour here. At one point, a Sour always called for lemon juice, not lime. At a later point, Sours usually had egg white added to them to give them a frothy head. Heck, a better name for this drink format would be the Sweet-and-Sour so let’s not get too hung up on that.

Regardless, with this basic recipe we can swap out ingredients and plug in others, but the sweet-to- sour balance is the key. As Attaboy bartender Sam Ross says, “The sweet and sour elements in a cocktail are like the pieces of bread in a sandwich. If they’re not in balance, the whole thing falls apart.”

The sour component of a Sour is usually lemon or lime juice, but it can be grapefruit or yuzu juice, or even muddled sour candy if that’s how you roll. The sweet component can be anything from a non- alcoholic sweetener like simple syrup, agave nectar, and grenadine to a liqueur like Cointreau or peach schnapps. It could even be an artificial sweetener like Sweet ‘N Low, though most bartenders would argue against that choice.

Then we can throw in anything else to the drink that doesn’t alter that sweet-to-sour balance. Egg whites are still used in vintage-style Whiskey Sours and all Pisco Sours to give them a nice foamy head and softer texture. Herbs and spices and bitters can provide accents as well.

A Sampling of Sours

Drink NameBase SpiritSour ComponentSweet ComponentExtras
Whiskey SourAmerican whiskeylemon juicesimple syrup(optional) egg white and bitters
Margaritatequilalime juicetriple sec(optional) salt rim
Mai Tai (original recipe)aged rumlime juiceorange curacao + orgeatmint sprig
Daiquirirumlime juicesimple syruplime wheel garnish
Jack Roseapplejacklemon juicegrenadine 
Lemon Droplemon vodkalemon juicesimple syrup(optional) sugar rim
Pisco Sourpiscolemon juicesimple syrupegg white and bitters
SidecarCognaclemon juicetriple seclemon zest and (optional) sugar rim

DIY Sours

Pick one of each and get started:

Base spirits: Vodka, gin, tequila, brandy/cognac, rum, pisco, bourbon, rye, scotch, cachaca, etc.

Sour elements: Lemon juice, lime juice, grapefruit juice, yuzu juice (make sure it’s unsalted). Note that orange juice and pineapple juice are rather sweet, so if you use those you’ll also want a sour juice in the drink as well. Most bartenders use lime.

Sweet elements: Raw sugar, simple syrup (equal parts sugar and water), agave syrup (equal parts agave nectar and water), honey syrup (equal parts honey and water), maple syrup, etc.

Extras: Herbs (mint, basil, oregano, etc.), spices (cinnamon, nutmeg, black pepper, hot sauce, etc.), egg white, garnishes (citrus zests, cherries, etc).

That 2:1:1 ratio ( 2 parts base spirit to 1 part sour to 1 part sweet) can change depending on a bar’s house style. A neighborhood bar might make drinks with a little less booze; while a modern speakeasy-style cocktail bar might emphasize the spirit by reducing both the sweet and sour. Some people like their Sours on the sweet side, while others may take a citrus-forward approach. Start with 2:1:1 proportions, find the balance that you like, and go forth and make many cocktails.

A note on sweeteners and sours: Some people use sweeter simple syrup than others – start with equal weights of sugar and water to make simple syrup (no need to heat it; it will dissolve if you're patient). When using thick agave nectar or honey, dilute it with equal parts of water. Keep in mind that lemons and limes are not the same sourness as each other, and they also change in tartness over the season. You’ll need to adjust the quantities to keep the drink in balance.

Advanced Level Sours

• The Cosmopolitan is actually a clever variation on the Sour with citrus vodka, triple sec, lime juice, and cranberry juice (which is both sweet and slightly tart), which requires rebalancing the other ingredients.

• Add soda water or another unsweetened filler to a Sour and you’ve got a whole new group of cocktails at your disposal (known as the Collins). A Mojito is a Rum Collins with Mint, which in turn is just a Daiquiri with soda water and mint. A French 75 is a Gin Sour with champagne as the filler. If you use a sweetened soda like ginger beer as a filler, you’ll need to reduce or eliminate the other sweet component.

• You can also use a sweet liqueur for the base spirit (as in the Amaretto Sour), but then you’ll want to seriously reduce the amount of the sweet element to rebalance the drink.

Aviation Cocktail
Camper English

    






When Cosmopolitan Sent A Victorian Lady To Race Around The Globe

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photos of Elizabeth Bisland and Nellie Bly taken during the time of their circumnavigation
Elizabeth Bisland and Nellie Bly
Bisland (left) and Bly (right) in their travel gear, in photos taken to publicize their race
Both photos are from the New York Public Library Archives

Sixteen years after Jules Verne first published Around the World in 80 Days, two American journalists raced to do just that. The Public Domain Review has the story, which is just about as charming as the Verne novel. The two women set off 124 years ago this month.

Nellie Bly, investigative journalist for the newspaper New York World, was the first to come up with the idea. She pitched it to her editors, then had to fight to go—her superiors originally wanted to send a man. After she'd set off, the editor of the monthly magazine The Cosmopolitan decided Cosmo* could get a lot of "pageviews" by sending a rival, preferably a young woman, to race Bly. So Cosmo recruited book reviews writer Elizabeth Bisland to go, starting in the opposite direction as Bly. The Public Domain Review tells the story mostly from the point of view of Bisland, who would eventually lose the race, circumnavigating the globe in 76 days to Bly's 75. I know, who wants to read about a loser? But this is cool because Bisland has never had as much written about her as Bly has. I'm a fan of circumnavigation efforts, and I never knew Bly had a rival. The author of The Public Domain Review article has also written a book about the two.

The Public Domain Review highlights works that are in the public domain, meaning their copyright no longer applies and people may view them and use them for free. Its Bly-Bisland article links to books and essays Bisland wrote throughout her life, including her descriptions of her trip. There are also contemporary photographs of ports she visited, as well as some weird anecdotes about how men at the time thought she was super hot. One writer called her "a sort of goddess," while another said she was "a beautiful dangerous leopard." A leopard? We just think she and Bly were really impressive. It can't have been comfortable to circumnavigate in the Victorian era.

It's always exciting to see real life echo science fiction… and here's a moment when that happened, more than a century ago.

*Yes, this is the magazine that would eventually become the fount of please-your-man-tips you know today.

[The Public Domain Review]


    






NASA's Tips For Interpreting Satellite Images

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satellite image of the Okanogan-Wenatchee National Forest in Washington state
Straight Lines Mark Off Land Parcels in a Mixed-Use Forest
NASA Earth Observatory image by Robert Simmon, using Landsat 8 data from the USGS Earth Explorer

Here at Popular Science, we love satellite images. They offer cool views of Earthly phenomena such as plankton blooms and erupting volcanoes. They give important perspective on the impact of natural disasters such as floods and fires. Seeing stuff from space can be a bit disorienting, however. But fear not. The Earth Observatory, NASA's public site for its Earth sciences, has listed some cool patterns to look for while interpreting satellite images. Some highlights:

  • A line of clouds can indicate there are mountains below, as the mountains push warmer air upwards to higher elevations, where it cools and forms clouds. A line of vortices in the ocean, on the other hand, can indicate there are peaks below the surface of the water, perturbing the water's flow.
  • There's an optical illusion called relief inversion that can happen with satellite images. Mountains appear to be canyons, or vice versa. The Earth Observatory explains:
    It happens because most of us expect an image to be lit from the top left corner. When the sunlight comes from another angle (especially from the lower edge), the shadows fall in ways we don’t expect and our brains turn valleys into mountains to compensate. The problem is usually resolved by rotating the image so the light appears to come from the top of the image.
  • Farmed plants often look brighter green than natural vegetation.
  • Smoke often looks smoother than clouds. Haze is featureless and may be opaque if it's dense, or translucent if it's thinner. It's not always possible to tell, just from visual inspection, the difference between white haze and natural fog.

Happy Earth-watching.

[NASA Earth Observatory]


    







A Hand-Crank GIF Player

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GIFs, those short, silent, looping animations found all over the internet, are wonderful. But what if some apocalyptic event wipes out the internet? How will you view your favorite GIF? The Giphoscope, by Italian designers Marco Calabrese and Alessandro Scali, is the solution: an analog GIF player, cranked by hand in a weird throwback to the early days of film.

Select a GIF or short video clip, and the designers turn it into 24 frames that fit in the Giphoscope, which measures about 4 inches by 5 inches. Each Giphoscope is custom built and costs 300 euros, or about $400. The full price includes not just the Giphoscope, but also photo updates on Google+ show your Giphoscope's assembly as it progresses.

Check out more completed Giphoscopes, like this one of motion picture pioneer Edward Muybridge's horse:

Muybridge's Horse

 

 


    






Wind Turbines Kill More Than 600,000 Bats A Year. What Should We Do?

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Wind Farm At Dusk

If you comb the ground beneath a wind turbine, you may not find anything out of the ordinary. Dead birds or bats are hard to find, especially considering the huge ground footprint of a wind turbine’s spinning blades. But this belies wind farms’ very real danger to migratory animals. Wind turbines kill a rather staggering 600,000 to 900,000 bats every year, according to a new study. But this does not mean we should start shutting down wind farms.

Dead bats have been found at almost every wind energy facility where someone has looked for them, and researchers have tried to use these numbers to estimate how many bats die every year. Mark Hayes, a postdoctoral researcher at the University of Colorado at Denver, analyzed published findings and places the number at more than 600,000. This number is probably conservative, he says in a new paper published in the December issue of the journal BioScience.

Though most of us think of bats as living in caves, many species roost in trees instead, and migrate across the continent in the fall to mate. These species include the hoary bat, which live alone as adults until mating season, when they travel in groups of hundreds.

“These bats migrate sometimes very long distances, from the Atlantic coast — Georgia, for example — up into the Great Plains,” Hayes said in an interview last week. “We don’t know a lot about their migratory patterns yet, but we’re studying it. They’re small and nocturnal, so we know much less about them than songbirds or butterflies, that sort of thing.”

Hoary Bat
USFWS/via Flickr

Hoary bats in particular use trees as landmarks, and biologists hypothesize that males might pick out the tallest tree around, circling it and calling for a mate.

“In many cases, the tallest tree on the landscape, or what looks like the tallest tree, is a wind turbine tower,” Hayes said. “So they’re using them to try to call in females. As they go through that process, they may either not be aware that these blades are rotating, or they may be distracted.”

Distracted is putting it mildly. Hayes once heard a story about a pair of mating bats that fell out of the sky in flagrante delicto, too caught up in their activities to realize they were no longer flying. “They get very distracted during this process,” Hayes said. “It may be one of the things that contributes to this.”

Wind turbines can kill bats in two ways: Blunt force and what’s called barotrauma. A tiny bat stands no chance against a turbine blade two train cars long, whirling at 150 MPH. Even if the bat isn’t struck, spinning turbines create changes in air pressure as they move, which can essentially cause the animals’ lungs to explode. But barotrauma may be less deadly than some biologists think, according to an analysis by the National Renewable Energy Laboratory.

All of this is not to say wind turbines are inherently bad or that we should stop building them. Hayes is emphatic that most biologists, himself included, support wind energy production. “It reduces carbon emissions, pollution, provides jobs and economic growth, so I see it as a net positive,” he said. “But at the same time, I think we have something of a responsibility to keep an eye on what’s happening.”
 
It may be very easy to have it both ways.

Wind Turbine Sunset
tlposcharsky on Flickr

Wind turbines generally turn on when the wind blows at a given speed, often around 3.5 meters per second (about 7.8 mph). This is known as the cut-in speed. Bats don’t like to fly when it’s windy, so wind farms may be able to slash bat fatalities by simply increasing cut-in speeds. A 2010 study by Bat Conservation International (PDF) showed faster cut-in speeds could reduce bat fatalities by 43 to 93 percent, with comparatively minimal losses in power generation. Reducing cut-in speeds during, say, a 6-week period during fall migration could therefore save hundreds of thousands of bats.

More studies have to be done to determine the optimal cut-in speeds and other factors, and exactly where the bats’ migration patterns might intersect wind farms — not to mention how many bats will be flying by. Biologists have no idea how many bats live in North America, within an order of magnitude. This makes conservation more difficult, to say the least.

“If you tried to ask me, ‘How many hoary bats are there?’ I wouldn’t even hazard a guess. It’s a difficult situation to be in,” Hayes said. “We’re starting to get a sense of how many bats are being killed, but we don’t know what proportion of the population that represents. Is it 1 percent, 5 percent, 0.1 percent? We don’t know. Given that we don’t know, I think it is a substantial concern.”

Basic research will help answer these questions, he said. “I think we can almost see solutions on the horizon.”


    






How Scientists Preserve Lincoln's Original Gettysburg Address Manuscripts

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The Gettysburg Address
Cornell University Library/Division of Rare and Manuscript Collections.

On November 19, 1863, Abraham Lincoln uttered the 10 sentences that would come to be known as the Gettysburg Address. His two-minute speech was part of the Gettysburg Cemetery’s lengthy dedication ceremony, which included a two-hour oration, prayers, and performances. Though Lincoln suggests that “the world will take little note, nor long remember what we say here,” 150 years later the speech is not only remembered, but considered one of the greatest in American history.

Lincoln penned five known copies of his Gettysburg speech. In fact, it’s likely that the copy accepted by historians as the standard (and final written in Lincoln’s hand) differs from what he delivered at the dedication. Researchers still study the variations in these documents’ histories, content, and physical properties. But what’s the best way to preserve these frail papers? Cultural conservators at the Library of Congress, the Abraham Lincoln Presidential Library and Museum (ALPLM), Cornell University and the White House, where the documents are housed, investigate the risks the documents face. Using an interdisciplinary approach, they determine and employ the best preservation procedures to stabilize the documents for future study and display.

The Five Manuscripts

All of the versions are on machine-produced rag paper, made from a combination of linen and cotton fibers. They’re all written in iron gall ink, one of the most ubiquitous inks of the time, except for the first version, which is in both iron gall ink and pencil. To keep the ink from absorbing into the paper and thus bleeding, most of documents are coated in a thin layer of gelatin. The first known document was written prior to the address, while the second was written either shortly before or (more likely) shortly after the address, Michelle Krowl, Civil War and Reconstruction specialist at the Library of Congress' Manuscript Division, tells Popular Science. The last three versions were written by Lincoln in 1864 as charitable donations.

The Exposure Problem

Light and pollutant exposure, temperature and humidity fluctuations, mishandling, manmade and natural disaster, and inherent material flaws are the leading causes of deterioration in most artifacts, says Debra Norris, chair of the art conservation department at the University of Delaware. Exposure to light, temperature and humidity accelerates the natural breakdown of the cellulose in paper fibers.

A previous owner covered it with cellophane to protect the document. The damage was irreversible.

Acid in papers and inks degrade the cellulose fibers of paper, as do acidic pollutants, such as nitrates and sulfates (the same chemicals responsible for acid rain). According to Michele Hamill, paper and photography conservator at Cornell University, the Gettysburg documents' naturally neutral and high-quality rag paper and well formulated, low-acid iron gall ink is part of the reason the manuscripts are in such good shape today. In addition, the gelatin coating provides a barrier between the acidic ink and the rag fibers.

Poor handling of the documents also caused damage to the addresses. The most severe example of mishandling is seen on the first page of Cornell’s manuscript. One of its previous owners covered it with cellophane to protect the document. However, some early versions of the plastic had a layer of nitrocellulose, a water repellant and low-grade explosive that Hamill suspects caused the damage. Thought it was only exposed to the cellophane for 15 years, the discoloration and damage was irreversible. Additionally, at least one copy has a fingerprint on it. The residue left by a fingerprint isn’t immediately visible, but the oils attract pollutants which speeds deterioration.

Photograph of Abraham Lincoln taken two weeks before his Gettysburg Address
Alexander Gardner

The Conservators’ Solution

Conservators receive rigorous formal training that is often compared to medical school, says Norris. The University of Delaware’s master’s program in art conservation is one of only four such programs in the U.S. Students learn the best storage conditions, how to trace an object's history, to evaluate its condition, to diagnose problems, and plan a course of treatment, if necessary. Cultural preservationists abide by the American Institute for Conservation of Historic and Artistic Works (AIC) code of ethics. Like the Hippocratic oath of the physicians they’re compared to, a central tenet of the AIC is to do no harm.

They were able to trace an embossment on the address to a stationery store near the capitol.

The most critical preventive measure is to maintain a stable and low temperature and relative humidity, and to eliminate as much light as possible. The Gettysburg manuscripts are kept between 50 degrees and 65 degrees F and between 40% and 48% relative humidity. While not on display, the documents are kept in almost complete darkness. Some versions of the address are kept in cases with no oxygen, which drastically reduces any oxidation caused by light. The papers are secured to acid-free mounts behind light-filtering plexiglass and stored in acid-free containers, to prevent acid transfer and harmful light damage.

When on display, the documents are carefully monitored for changes in condition, and light exposure is minimized with very low exhibition lighting, according to Bonnie Parr of the ALPLM. She measures the museum’s version of the address to see how its dimensions change in various conditions. Additionally, high-quality replicas are on hand to replace the originals, so as not to risk overexposure.

These preventive measures minimize the need for restoration, but in some cases, additional interventions are required to stabilize documents. These interventions should ideally be reversible, in the case better technology becomes available. When they aren’t, it’s important to weigh the possible gains and losses. Because the iron gall ink was causing acid build-up on the ALPLM’s document, conservators decided in 1995 to deacidify the back of the document. Several of the versions have also had minor tears fixed with neutral strips of paper and starch-based paste.

Why It Matters

With the quality of digital scanning and immense amount of research on these documents, why should we waste time on the originals? Aside from the historical significance of the text itself, there’s still plenty to be learned from the objects. Hamill describes the history of the documents and their recent discoveries in a series blog posts for Cornell's library. Using digital imaging and comparing notes with Krowl at the Library of Congress, they were able to trace an embossment on the address to a stationery store near the capitol. Understanding this supply chain could help historians trace the path of paper during the Civil War, at which time it was incredibly rare.

But beyond these research opportunities, Norris says cultural preservation is essential to cultural identity. “It’s about connecting communities. It’s about reconciliation. It’s about building literacy,” she says. “A lot of these really fundamental world challenges can be addressed in some way through the preservation of cultural heritage.”

See one of the original versions of the address through Sunday at the Abraham Lincoln Presidential Library and Museum in Springfield, Ill.; through Saturday at the Cornell University Library in Ithaca, NY; and through January 4 at the Library of Congress in Washington, D.C.


    






Xbox One Review: I'm Sorry I Raised My Voice

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Xbox One
Microsoft

I wouldn't say a lost my temper with the Xbox One. Because I actually, for the most part, enjoyed the experience. But I did raise my voice. And for that I apologize. 

Everything about Microsoft's new game console, its first in eight years, is designed to make you do as little as possible. That means running multiple apps at the same time, a "snap" function to plop stuff on-screen into a picture-in-picture style, and--eek--a reliance on voice controls. 

I share the blame, Xbox One. I do. I am a mumbler. I have difficulty expressing myself at times. I rushed too quickly to say Xbox One, get it together, to which you pulled up the "weather" option. (Ha! Defusing the situation. You are too funny, Xbox One.)

Anyway.

We should let it go. Because I liked you, Xbox One. We should talk more. Later, though. Now's a bad time.

How It Looks

Oof. All right, then. Let's just get the worst thing out of the way. The Xbox One is a not-particularly-attractive behemoth of a game console. It's the size of a small suitcase and heavy as one stuffed with sheet-metal. The shape is hard to describe beyond "box"--very few ridges, curves, or any other shapes to variate the monolithic design. It's like a VCR that's metastasized in your living room. I thought I had reserved ample room for any console, since that had been the case for any other console I've put there. That was not the case. If you are planning to travel with the Xbox One, remove those plans from your itinerary. Actually, whatever table or surface you place it on, be prepared to keep it there forever. Actually, just be prepared to die in whatever home/apartment/cavern you currently reside in. The Xbox One isn't going anywhere.

There's also a new controller. There are a list of changes Microsoft has been touting--like a vibrate function on the triggers, and a redesigned, less bulky spot for the batteries--and, yeah, it's a little better. But the truth is in practice it doesn't feel all that different, at least when stacked up to the more drastic changes Sony made to its controller for the new PlayStation 4. If you were a huge fan of the Xbox 360 controller, then fine, you'll be happy with this. Otherwise, if you're looking for huge changes in the console, you'll have to find something elsewhere. 

Booting Up

If you've set up any console in your life, the Xbox One set-up will be painless: connect the wire in back to the wall, the other wire to the TV, etc. There is one extra step, though, that I'd recommend taking the time to do: the new Xbox can also be wired through your cable-box through HDMI, allowing you to watch TV by selecting it on the Xbox's main screen. (Same goes for the HDMI-friendly media streamer of your choice; I used a Roku.) More on that in a minute. 

Here I should mention: I think but can't readily confirm that I had a glitch with my Xbox. When I first booted up the console, it took me straight to the Xbox's home screen, without the usual registration process. There, the controller wouldn't function properly. I don't know who, if anyone, will have this issue, but it was solved after a quick reset. 

Here I should also mention: the reset process takes forever. You boot up, are brought to the big, green Xbox One load screen, and then you go grab a snack or take out the garbage or something while you wait it out. Unfortunate, since the Xbox One home screen actually looks pretty nice after it's done loading. Microsoft's tile system, which is now loaded on every one of its devices, is here again, and doesn't look too different from the last Xbox incarnation. Things are little more organized, and the Xbox automatically moves the titles for apps and games you played most recently to the front of the screen, assuming that those are what you'll most likely use again. Notifications pop up on the bottom of the screen in much the same way as last time around, and there are the same slots reserved for places where you can buy games, apps, and music. (An image of an angsty Eminem promoting some tunes has been permanently etched into my brain.) But there's a greater focus on features besides games. Which brings us to...

Ryse: Son of Rome
Crytek

Under The Hood

I said this in my PlayStation 4 review, but I'll say it again: the specific technical details in a system aren't as important as the functionality you get from those specs. That said, it has similar specs to the PlayStation 4: a combination of CPU and GPU processors meant to divide the work of processing graphics and other tasks. But the results are a little different: the biggest change behind the Xbox One--and the best one--is the ability to instantly stop playing a game with a single button and enter your home screen. No more save-and-quit, no more shutting off one thing to open up something else. The processors divert processing power to the game, and the rest goes to the ancillary apps. None of that affected the performance of either, in my experience. That's a big deal. You can turn on a dime with the Xbox One, not feel stuck because you're playing a game and suddenly realizing there was something else you wanted to do first. Then, once you're done with your other task, you go back directly to the game, picking up exactly where you left off. 

Now I can simply run my Roku through the Xbox instead of going directly through the TV.

There's also a new Kinect, Microsoft's motion-capturing camera that comes bundled with the new Xbox One. And it's better, with a wider range of vision and better resolution--enough to scan your face to sign you in. (I'll go on record, again, saying this still gives me the heebie-jeebies. But it's also undoubtedly cool tech.) As much as I disdain voice controls, the commands I sent to the Kinect worked okay. Not great, just fine. Although since certain functions, like the otherwise great "snap" function, which lets you pull up a separate window to multi-task, rely wholly on the technology, it should be flawless, even at a whisper. (Update for clarification: You can manually select the snap function with a controller on the homescreen, but, obviously, to switch between functions when you're already doing something, you'll need to use voice control.)

But I do love the option of routing my cable box or media streamer through my Xbox. Between multiple game consoles and a Roku, I'm already taking up a lot of wire and wall space. Now I can simply run my Roku through the Xbox instead of going directly through the TV. After that, just select the TV option on the Xbox home screen, and you're directed to your TV. Maybe that's not life-changing, but it frees up a wire and a little time if I want to multi-task between gaming and TV-watching. 

Games

Here it is! Games! For the game console. The PlayStation 4 lineup turned out to be incredibly underwhelming, but the Xbox One lineup, oh man, let me tell you: it is also incredibly underwhelming.

I'll start with the positive: Ryse: Son of Rome, a semi-melodramatic sword-and-sandals epic, probably takes too much glee in its eviscerations of barbarians, but looks like it could be one of the bright spots at launch, as one of the only truly original properties in the stable. 

Now the bad: a digital title called Crimson Dragon is one of the worst games I have played in recent memory. You ride a space dragon that shoots, like, missiles at other space dragons. There's some kind of government conspiracy. Or aliens? No, wait, you're the alien. Maybe. I don't know. 

There's another installment in the Forza racing game franchise that certainly looks nice on the new system, but doesn't seem to offer much beyond the standard racing game fare. There are a few new sports games, the animal-management bureaucracy simulator Zoo Tycoon, and a slew of titles that have already appeared on the last system. As disappointing as Sony's list of games turned out to be, you're not going to find much on Microsoft's end, either. 

Should You Buy This?

No. Wait. You don't need something to hook up through your TV right now, unless it has games to accompany it, and the Xbox One, as cool as some of its features are, has a dearth of games. You can wait. How long? That's up to you: whenever there's a sum of games that make it worthwhile to you, go for it. (That could theoretically be right now, but I'll venture to say it isn't, even for even the most die-hard gamers.)

Now comes the point where I tell you whether the Xbox One or PlayStation 4 is the King of the Console Generation. But I'm not going to do that--especially this early. I might sound overly diplomatic here, but there are reasons to root for both. I wasn't a huge fan of the PS4, but at $400, it's $100 cheaper than the Xbox One. The interface isn't as forward-thinking, but maybe you want something that puts more focus on games. Maybe, too, you want something more mobile. 

Regardless, though, the most important part of a system is still games. And it remains to be seen which console will make the biggest leaps in that field. You can wait to find out. 


    






Keep Your Keys In The Cloud And Have Them Delivered When You Need Them

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KeyMe, the company that brought robot locksmiths and photo-copy-able keys to New York, is launching a new service. This time, there's not much new technology involved. You'll just be able to get your robot-made key copy delivered to you, by a person, via the KeyMe app. "Our goal is to be 24 hours and to be able to help you out whenever you need a key," KeyMe CEO Greg Marsh tells Popular Science.

Using KeyMe still requires some foresight. Before you accidentally lock yourself out anywhere, you need to have scanned your key, either at a kiosk or using your iPhone. KeyMe saves a digital file of your key's shape, which you're then able to easily access any time you want a key. Besides getting the key delivered, you can go to one of KeyMe's robotic kiosks to get a key cut for you, or you can mail-order copies of your keys through the app. 

One-hour personal delivery costs $59. Three-hour delivery costs $20. For now, delivery is only available from 10 am to 9 pm, Monday through Saturday, anywhere in Manhattan south of 125th Street. Marsh says the company plans to extend hours in the future and to provide service to the outer boroughs. It also plans eventually to offer deliveries in Boston. The company partners with local locksmiths to cut the keys and make the deliveries.

photo of shelving in the KeyMe office, presumably holding orders
Shelving in the KeyMe Office
KeyMe

Meanwhile, since the KeyMe robot kiosks launched in June, the KeyMe algorithms have undergone updates, Marsh says. The algorithms are the coolest technology the company has: they are able to infer a key's three-dimensional shape from a photograph of it. As more people have signed up for KeyMe and allowed the company to scan their keys, company engineers have used that pool of digital data to teach their algorithms how to better recognize key shapes.

Nevertheless, the algorithms can fail, with strange results. A friend of mine tried to copy his key at a kiosk, but got a non-working key in return. Afterward, KeyMe sent him a $5 Amazon gift certificate, although he had not complained to the company. "They knew somehow," he says (You can see much of our conversation on Twitter). "I guess they could tell the scan was wonky."

Impressed, he tried again, but then the kiosk gave him an entirely uncut key.

"These are related errors, so your friend's key was giving our kiosk trouble for some reason," Marsh says. "Although errors are not common, they can be caused by unusual geometrical features on the key or a hardware malfunction in the kiosk." Let KeyMe know if their algorithms fail you, Marsh says. The company will provide a refund, a free set of keys and an Amazon gift card.


    






Vancouver Banned Doorknobs. Good.

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Doorknob

In Vancouver, the humble doorknob is being phased out. Kind of. Effective in March, new housing will be required to install levers on doors and faucets, instead of the good-ol' round knobs of our forefathers. 

Cue: libertarian cries of government overreach and nanny-state-ism and evil G-men in suits entering homes and stealing all of our doorknobs despite our constitutional right to them. Fine. But anyone against the idea might feel differently when they're pushing 80. 

The idea behind Vancouver's decision is that, despite being of a more vintage grade than levers, doorknobs kind of suck. Ergonomics studies investigating different types of water-dispersing mechanisms have shown that lever-style faucets are far preferable to their knob counterparts. (Yes, there are studies for everything.) Knobs, you see, involve pronating and supinating your wrist, (stretching it, basically) which is less fun for everyone, but probably won't make you run out and immediately and switch to levers. Maybe you like your nice art deco knobs. 

Unless, that is, you're elderly. You get older, maybe you get arthritis, and this doorknob-to-lever issue stops being academic. Other studies have shown that the type of handle a door has is important to the elderly, and that lever-style knobs function better. One of the most in-depth studies I could dig up, a look at homes for the elderly in Malaysia, went so far as to study the actual measurements of people in homes for the elderly, and apply that to ergonomic door design. A snippet of the team's findings: 

The minimum door height should comply with the stature anthropometry of the 95th percentile male (72.60 cm). The door width should be the elbow span of the 95th percentile male (97.4 cm). A lever-type doorknob should be positioned at the elbow height of the 5th percentile female (81.60 cm).

And with Americans (and Canadians!) living longer, this will only become a bigger issue. According to the Centers for Disease Control, an estimated 67 million adult Americans will have arthritis by 2030. For them to have a more productive life, they'll need doors that are easier to open. You can't throw a fit about the law unless you're also against mandatory wheelchair ramps for businesses. 

Plus, the Vancouver law isn't retroactive anyway. If your building has doorknobs, they get grandfathered in. 

But for new buildings? Good riddance. We have been pronating and supinating like fools for too long.


    






Everything You Thought About Amateur Biotech Is Wrong

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The Wilson Center today released a report debunking the media myths surrounding the Do-It-Yourself Biology movement, called “Seven Myths and Realities about Do-It-Yourself Biology” based on my survey of the community earlier this year. I hope the report can move the conversation beyond just biosecurity and finally get us to the fun part where we focus on opportunities. 

You can read the editorial in Slate, or let the report speak for itself. Here’s an excerpt from the conclusion:

The DIYbio community is not an anonymous threat to public biosafety and security. Rather, the movement provides a new channel for public science engagement and education and a broad opportunity for economic and scientific innovation. Though still in the early phases of development, the community has already shown promise in all these areas.

The negative portraits drawn by policymakers and media mismatch the survey data. DIYbio shows a well-networked community that
is aware of the risks and ethics related to biotechnology. The data also shows that DIYers are almost exclusively working with BSL 1 organisms, rather than the pathogens imagined in the press. At present, very few DIYers are actually engineering genes, but that number stands to grow as the technology becomes easier and more reliable.

It is in the interest of academia, industry, and government to foster these communities through grants, access to equipment, and shared expertise.

As the DIYbio movement grows and becomes more technically adept, greater governance may be required. However, contrary to news reports, the community is already actively engaged in developing codes of conduct, developing safety protocols, and discussing the various regulations that may affect it. To harness this community’s potential to provide biotech innovation, education, and awareness, policymakers should treat the community as a valued stakeholder within the larger biotech community and include it in future policy discussions.

 

 


    







How International Guidelines For Lab Mice May Interfere With Cancer Research

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photo of a gloved hand, holding a mouse
The Long-Suffering Lab Mouse
Oak Ridge National Laboratory

Given the choice, a mouse wouldn't keep his house at what's considered "room temperature" for people. Mice are smaller. They lose heat faster. They generally like hanging out in places that are about 30 degrees Celsius (86 degrees Fahrenheit), but international guidelines for lab mice say they should be kept at human room temperature, 20 to 26 degrees Celsius.

Now, a new study says such guidelines could have a profound effect on studies done in lab mice. Mice kept in the recommended temperature range formed and grew tumors more quickly than mice living in their own preferred temperature, the study found. The chilly mice also didn't mount as much of an immune system response against tumors as comfy mice.

This doesn't mean you can justify turning up the heat in the winter as cancer prevention. (That is an issue you just need to talk out with your roommates, okay?) Instead, it suggests that first-line health studies done in mice—of which there are an enormous number—may all have this flaw. Immune system-based therapies are under intense research right now, but lab mice's living conditions may make the treatments seem less effective than they truly are, the researchers wrote in their paper, published in the Proceedings of the National Academy of Sciences.

One interesting finding from the study that underscores the importance of temperature: Given a choice of five chambers kept at different temperatures, mice with tumors preferred the warmest one, at 38 degrees Celsius, although healthy mice usually prefer the 30-degree room. This suggests tumor-stricken mice feel colder than their healthy peers. Ars Technica points out human breast cancer patients have complained of feeling cold, too.

The Scientist talked to several researchers not involved in the study about how this will impact cancer science.  One cancer therapy researcher told the magazine, "Everybody thought that mice would be fine at room temperature, but nobody ever thought to look," while another called the study "a game-changer."

[Ars Technica, The Scientist, Nature News]


    






Happy 15th Birthday, International Space Station!

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Rendering of the ISS
Popular Science May 1998

Fifteen years ago today, the Russian Space Agency launched the first component of the International Space Station into orbit. The piece was a pressurized module called Zarya, which means sunrise. Two weeks later, the U.S. shipped their own ISS component, Unity, on the shuttle Endeavour. Piece by piece, the station was assembled with parts from various countries. Humans didn't arrive until October 31, 2000, when one NASA astronaut and two Russian cosmonauts traveled to their new orbiting home. There have been 37 expeditions since then, and ISS inhabitants have logged nearly 1,100 hours in spacewalks. 

In May 1998, Popular Science dedicated an issue to the International Space Station in advance of the historic Russian mission. The issue (complete with pullout space station poster!) speculated on how astronauts would live in space for prolonged periods of time, the research that would be conducted onboard the ISS, the eventual decommission plan, and more. You can read these stories over in our archive.

A lot has been accomplished aboard the ISS, and it's hard to remember a time when we didn't have an orbiting extension of humanity. So, wave hello with special gusto if you spot the Space Station overhead tonight.

May 1998 issue of Popular Science

    






Allow Wu-Tang Clan's GZA To Rap To You About The Big Bang

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Rapper GZA, of Wu-Tang Clan fame, is releasing a space-themed album called Dark Matter. He's even been chatting with astrophysicist Neil deGrasse Tyson about the project. Here, as part of a talk at the University of Toronto, he previewed an a cappella version of one track. It's about the Big Bang. And it is tremendous. 

[Mashable]


    






Readers Respond: Don't Touch Our Doorknobs

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Lever Handle

In a post this morning, I wrote that Vancouver's plan to ban doorknobs from being implemented in new buildings in favor of lever-style handles was a great idea. Doorknobs are less ergonomic, and an aging population might appreciate the switch.

Many readers on social media disagreed. Fervently. 

Here's a sampling of some comments from Facebook and Twitter, organized by some of the most common criticisms:

WHAT ABOUT THE CHILDREN:

Commenters pointed out that it's easier for dogs/cats/children to work a handle than a doorknob:

Door knobs aren't bad. They're the only thing keeping my pets from opening doors on their own!--Rayna Montez, via Facebook

God forbid people decide what sort of door hardware they prefer in their houses. Sometimes knobs are preferred when kids and clever animals are around.--Chris Ferguson, via Facebook

THE SLIPPERY SLOPE ARGUMENT: 

What's next? A perfectly ergonomic world? But at what cost?

The libertarian complaints are well warranted, why should states infer like this. What happens if a new study finds that the color red improve moods... should all new houses be forced to paint only in red? Preventing people from making their own choices in the name of such cute utility arguments is a really nasty downward slope.--Thomas Egebak, via Facebook

While we're at it, let's ban stairs. From now on, ONLY ramps are allowed /snark/--Dan Ader, via Facebook

Levers make sense ergonomically but as a dwindling member of a once free society I object to statists mandating how I live.--Philip Wilson, via Facebook

THE MOST CONVINCING ARGUMENT:

I stand by my original points. But there was one counter-argument that truly made me pause.

If Jurassic Park is any warning, levers cannot stop Velociraptors!--Chris Ferguson, via Facebook

Paving the way for Velociraptors to eat all of us....--Bud Atherton, via Facebook

Its clear I am not the only one deeply concerned about the risk this poses to velociraptor infested areas. These fools will get us all killed!!!!--Ethan Surbaugh, via Facebook

To these last points I can only say: there is definitely NOT a raptor at my desk right now who forced me into this line of argument. DO NOT SEND HELP IMMEDIATELY.

You can add more opinions to the comments section here. 


    






Art on the Mind

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©Maki Naro

Hey New Yorkers, tonight (11/20) at ABC No Rio is the opening reception of Collect, Store, Retrieve, an exploration of the "mechanics, makeup, fallibility, and plasticity of memory." The show is curated by Brian George and Kelly Savage and is funded in part with support from the New York City Department of Cultural Affairs and the New York State Council on the Arts. Brian had this to say about it:
 

The basic idea for the show came about when I was thinking about current scientific research into memory—how it is formed, how it changes over time, how unreliable human memory can be, and so forth. More or less the mechanics of memory. My wife and I are members of the visual arts collective at ABC No Rio and so we proposed an exhibition based on this idea. Along with the VA collective, we expanded on the concept and extended invitations to some artists who we thought would do well with the subject. We gave them jumping off points for how to approach the show, such as Memory as experienced by moving from one culture to another; The science of memory; False memories; Shared memories (people, places, events); Nostalgia; Sense memory (smells, tastes) and so on. 

The artists delivered and came up with quite diverse concepts including loss, frustration with trying to remember something unsuccessfully, the relationship between memory and things, the fading and mis-remembering of memory over time and much more. Mediums represented in the show include illustration, cut paper, photography, painting, bookbinding and sequential art.

Collect, Store, Retrieve will be up until December 10, and features artwork by Brian George, Kelly Savage, Mónica Félix, Michelle Harvey, Carla Hernandez, and myself. Tonight's reception begins at 7pm. Hope to see you there!

(Via ABC No Rio)

For more of the above, check out my other comic, Sufficiently Remarkable, a story about learning the hard way that you're always coming of age. Updates Mondays and Fridays.

You can also learn more about the intersection of art and science over at Mad Art Lab, where Brian is a regular contributor.

Illustration by Brian George

    






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